Rekombinanter ErbB2/Her2 Antikörper

Produktnummer ABIN7795221

Der Humanized Monoklonal anti-ErbB2/Her2 Antikörper wird verwendet zum Nachweis von ErbB2/Her2 in Proben von Human. Er wurde validiert für ELISA, Func, IGA und Neut.

Kurzübersicht für Rekombinanter ErbB2/Her2 Antikörper (ABIN7795221)

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Humanized

Klonalität: Monoklonal

Konjugat: Dieser ErbB2/Her2 Antikörper ist unkonjugiert

Applikation: ELISA, Functional Studies (Func), Immunogenicity Assay (IGA), Neutralization (Neut)

Güteklasse: In vivo Grade

Klon: 4D5 (muMAb)

Produktdetails anti-ErbB2/Her2 Antikörper

Expressionssystem: Mammalian cells

Verwendungszweck: In vivo Grade Recombinant Anti-Human HER2/ErbB-2/c-neu monoclonal Antibody, Mouse IgG1 Kappa

Produktmerkmale: Trastuzumab, a humanized monoclonal antibody (clone HuMAb 4D5-8), interferes with the HER2/neu receptor and is mainly used to treat certain breast cancers, especially HER2-positive metastatic breast cancer. Combined with chemotherapy, trastuzumab increases both survival and response rate. There are four closely related receptor tyrosine kinases in the ErbB family of receptors: EGFR (ErbB-1, HER1 in humans), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Bound by members of the epidermal growth factor family (EGF-family) of extracellular protein ligands, the HER receptors embedded in the cell membrane promote cell growth and division by turning genes on and off. The HER2 pathway stimulates cell proliferation if it normally functions, when HER2 is overexpressed, cell growth accelerates beyond its normal limits, which happens in some cancers, notably certain types of breast cancer.

Aufreinigung: Protein A or G affinity column

Reinheit: >95 % by reducing SDS-PAGE

Endotoxin-Niveau: < 1 EU per 1 mg of the protein by the LAL method

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: > 3 mg/mL

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short time 2 to 8°C as supplied. Long time -20°C to -70°C as supplied.

Details zu ErbB2/Her2

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Andere Bezeichnung: HER2

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Skeletal Muscle Fiber Development