LHB Antikörper

Produktnummer ABIN7794912

Der Maus Monoklonal Anti-LHB Antikörper wurde für validiert. Er ist geeignet, LHB in Proben von Human zu detektieren.

Kurzübersicht für LHB Antikörper (ABIN7794912)

Target: LHB (Luteinizing Hormone beta Polypeptide (LHB))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LHB Antikörper ist unkonjugiert

Applikation: Bitte anfragen

Klon: 196

Produktdetails anti-LHB Antikörper

Verwendungszweck: Anti-Human Luteinizing Hormone (LH)-Purified (Clone 196)

Spezifität: Mouse Anti-Human Luteinizing Hormone Beta (LH=?) (Clone 196) recognizes Human Luteinizing Hormone Beta. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. Background Luteinizing hormone (LH) is a hormone synthesized and secreted by gonadotropes in the anterior lobe of the pituitary gland. In concert with the other pituitary gonadotropin follicle stimulating hormone (FSH) it is necessary for proper reproductive function. In the female, an acute rise of LH - the LH surge - triggers ovulation. In the male, where LH had also been called Interstitial Cell Stimulating Hormone (ICSH), it stimulates Leydig cell production of testosterone. LH is a glycoprotein. Each monomeric unit is a protein molecule with a sugar attached to it, two of these make the full, functional protein. Its structure is similar to the other glycoproteins, FSH, TSH, and hCG. The protein dimer contains 2 polypeptide units, labeled alpha and beta subunits that are connected by two disulfide bridges. The alpha subunits of LH, FSH, TSH, and hCG are identical, and contain 92 amino acids. The beta subunits vary. LH has a beta subunit of 121 amino acids (LHB) that confers its specific biologic action and is responsible for interaction with the LH receptor. This beta subunit contains the same amino acids in sequence as the beta sub unit of hCG and both stimulate the same receptor, however, the hCG beta subunit contains an additional 24 amino acids, and both hormones differ in the composition of their sugar moieties. The different composition of these oligosaccharides affects bioactivity and speed of degradation. The biologic half-life of LH is 20 minutes, shorter than that of FSH (3-4 hours) or hCG (24 hours).

Immunogen: Purified Recombinant Human LH-beta (>98%)

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 μg/mL

Buffer: This purified antibody is supplied in 0.01 M phosphate buffered saline (PBS), pH 7.4, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For long term storage freeze working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Details zu LHB

Target: LHB (Luteinizing Hormone beta Polypeptide (LHB))

Andere Bezeichnung: Luteinizing Hormone Beta

Substanzklasse: Hormone

Hintergrund: LH,

Pathways: Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity, C21-Steroid Hormone Metabolic Process