CCKBR Antikörper (AA 301-400)

Produktnummer ABIN734318

Es sind 4+ Publikationen für dieses Produkt verfügbar. Der Kaninchen Polyklonal anti-CCKBR Antikörper wird verwendet zum Nachweis von CCKBR in Proben von Maus und Ratte. Er wurde validiert für WB, ELISA, IF (cc), IF (p), IHC (p) und IHC (fro).

Kurzübersicht für CCKBR Antikörper (AA 301-400) (ABIN734318)

Target: CCKBR (Cholecystokinin B Receptor (CCKBR))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CCKBR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-CCKBR Antikörper

Bindungsspezifität: AA 301-400

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Cow,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Gastrin receptor

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-CCKBR Antikörper (ABIN734318)

Eberhard, Kirkeby, Hansen, Cayé-Thomasen: "Neurotransmitter and neurotransmitter receptor expression in the saccule of the human vestibular system." in: Progress in neurobiology, Vol. 212, pp. 102238, (2022) (PubMed).

Liu, Banerjee, Herring, Attalla, Hu, Xu, Shao, Simmons, Dadi, Wang, Jacobson, Liu, Hodges, Lau, Gu: "Neurog3-Independent Methylation Is the Earliest Detectable Mark Distinguishing Pancreatic Progenitor Identity." in: Developmental cell, Vol. 48, Issue 1, pp. 49-63.e7, (2019) (PubMed).

Mohammad, Ozaki, Takeuchi, Unno, Yamoto, Morioka, Takiguchi, Ikeda: "Functional compensation between cholecystokinin-1 and -2 receptors in murine paraventricular nucleus neurons." in: The Journal of biological chemistry, Vol. 287, Issue 47, pp. 39391-401, (2012) (PubMed).

Kalsheker, Hodgson, Watkins, White, Morrison, Stockley: "Deoxyribonucleic acid (DNA) polymorphism of the alpha 1-antitrypsin gene in chronic lung disease." in: British medical journal (Clinical research ed.), Vol. 294, Issue 6586, pp. 1511-4, (1987) (PubMed).

Details zu CCKBR

Target: CCKBR (Cholecystokinin B Receptor (CCKBR))

Andere Bezeichnung: Gastrin receptor/GASR/CCKBR

Hintergrund:

Synonyms: GASR, CCK-B, CCK2R, Gastrin/cholecystokinin type B receptor, CCK-B receptor, CCK-BR, Cholecystokinin-2 receptor, CCK2-R, CCKBR, CCKRB

Background: Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.

Gen-ID: 887

UniProt: P32239

Pathways: Positive Regulation of Peptide Hormone Secretion, Feeding Behaviour