CCKBR Antikörper (AA 301-400)

Produktnummer ABIN734318

Der Kaninchen Polyklonal Anti-CCKBR-Antikörper wurde für WB, ELISA, IF (cc), IF (p), IHC (p) und IHC (fro) validiert. Er ist geeignet, CCKBR in Proben von Maus und Ratte zu detektieren. Es sind 4+ Publikationen verfügbar.

Kurzübersicht für CCKBR Antikörper (AA 301-400) (ABIN734318)

Target: CCKBR (Cholecystokinin B Receptor (CCKBR))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CCKBR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-CCKBR Antikörper

Bindungsspezifität: AA 301-400

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Cow,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Gastrin receptor

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-CCKBR Antikörper (ABIN734318)

Eberhard, Kirkeby, Hansen, Cayé-Thomasen: "Neurotransmitter and neurotransmitter receptor expression in the saccule of the human vestibular system." in: Progress in neurobiology, Vol. 212, pp. 102238, (2022) (PubMed).

Liu, Banerjee, Herring, Attalla, Hu, Xu, Shao, Simmons, Dadi, Wang, Jacobson, Liu, Hodges, Lau, Gu: "Neurog3-Independent Methylation Is the Earliest Detectable Mark Distinguishing Pancreatic Progenitor Identity." in: Developmental cell, Vol. 48, Issue 1, pp. 49-63.e7, (2019) (PubMed).

Mohammad, Ozaki, Takeuchi, Unno, Yamoto, Morioka, Takiguchi, Ikeda: "Functional compensation between cholecystokinin-1 and -2 receptors in murine paraventricular nucleus neurons." in: The Journal of biological chemistry, Vol. 287, Issue 47, pp. 39391-401, (2012) (PubMed).

Kalsheker, Hodgson, Watkins, White, Morrison, Stockley: "Deoxyribonucleic acid (DNA) polymorphism of the alpha 1-antitrypsin gene in chronic lung disease." in: British medical journal (Clinical research ed.), Vol. 294, Issue 6586, pp. 1511-4, (1987) (PubMed).

Details zu CCKBR

Target: CCKBR (Cholecystokinin B Receptor (CCKBR))

Andere Bezeichnung: Gastrin receptor/GASR/CCKBR

Hintergrund:

Synonyms: GASR, CCK-B, CCK2R, Gastrin/cholecystokinin type B receptor, CCK-B receptor, CCK-BR, Cholecystokinin-2 receptor, CCK2-R, CCKBR, CCKRB

Background: Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.

Gen-ID: 887

UniProt: P32239

Pathways: Positive Regulation of Peptide Hormone Secretion, Feeding Behaviour