ALIX Antikörper

Produktnummer ABIN7673519

Dieser Maus Monoklonal Antikörper erkennt spezifisch ALIX in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für ALIX Antikörper (ABIN7673519)

Target: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ALIX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Klon: 8H4

Produktdetails anti-ALIX Antikörper

Verwendungszweck: PDCD6IP antibody

Aufreinigung: protein A+G purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: programmed cell death 6 interacting protein

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu ALIX

Target: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Andere Bezeichnung: PDCD6IP

Hintergrund:

Synonyms: Programmed cell death 6-interacting protein (PDCD6-interacting protein)|ALG-2-interacting protein 1|ALG-2-interacting protein X|Hp95|PDCD6IP|AIP1|ALIX|KIAA1375

Background: This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15.

Molekulargewicht: 100 kDa

Gen-ID: 10015

UniProt: Q8WUM4

Pathways: p53 Signalweg, EGFR Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Tube Formation