PD-L1 Antikörper (FITC)

Produktnummer ABIN7673108

Dieses Maus Monoklonal-Antikörper erkennt spezifisch PD-L1 in FACS. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für PD-L1 Antikörper (FITC) (ABIN7673108)

Target: PD-L1 (CD274 (PD-L1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PD-L1 Antikörper ist konjugiert mit FITC

Applikation: Flow Cytometry (FACS)

Klon: 9F7

Produktdetails anti-PD-L1 Antikörper (FITC)

Verwendungszweck: FITC Anti-Human CD274/PD-L1 Antibody

Aufreinigung: 0

Reinheit: 0

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Volume per test: 5μL. Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 μL of antibody per test (million cells in 100 μL staining volume or per 100 μL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0. 1 % sodium azide, 1 % BSA, pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: 4 °C

Informationen zur Lagerung: 2-8°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu PD-L1

Target: PD-L1 (CD274 (PD-L1))

Andere Bezeichnung: CD274

Hintergrund:

Synonyms: B7-H1|PD-L1|Programmed cell death ligand 1|B7 homolog 1|B7-H|B7H1|PDL1|PDCD1L1|PDCD1LG1

Background: CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

Molekulargewicht: 0

Gen-ID: 29126

UniProt: Q9NZQ7

Pathways: Cancer Immune Checkpoints