CXCR3 Antikörper

Produktnummer ABIN7673000

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CXCR3 in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für CXCR3 Antikörper (ABIN7673000)

Target: CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CXCR3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Klon: 6F7

Produktdetails anti-CXCR3 Antikörper

Verwendungszweck: CXCR3-specific antibody

Aufreinigung: Protein A+G purification

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: peptide(N-terminal,extracellular domain)

Immunogen: chemokine(C-X-C motif) receptor 3

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:5000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu CXCR3

Target: CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

Andere Bezeichnung: CXCR3

Hintergrund:

Synonyms: C-X-C chemokine receptor type 3 (CXC-R3, CXCR-3)|CKR-L2|G protein-coupled receptor 9|Interferon-inducible protein 10 receptor (IP-10 receptor)|CXCR3|GPR9

Background: CXCR3(C-X-C chemokine receptor type 3) is a G protein-coupled, seven-transmembrane domain chemokine receptor that is expressed on the surface of a number of cell types, including activated CD4+ and CD8+ T cells, NK and NK-T cells, plasmacytoid dendritic cells, and some B cells(PMID: 16847335). CXCR3 binds and is activated by the three IFN-gamma-inducible chemokines: CXCL9, CXCL10, and CXCL11. Binding of these ligands to CXCR3 has been implicated in regulating T-cell infiltration during inflammation and tissue injury(PMID: 17250586). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms, CXCR3B, mediates the angiostatic activity of CXCR3 ligands and also acts as functional receptor for CXCL4(PMID:12782716). This monoclonal antibody is specific to CXCR3B.

Molekulargewicht: 40 kDa+43 kDa

Gen-ID: 2833

UniProt: P49682