RANKL Antikörper

Produktnummer ABIN7670758

Dieses Anti-RANKL-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von RANKL in ELISA. Geeignet für Human.

Kurzübersicht für RANKL Antikörper (ABIN7670758)

Target: RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RANKL Antikörper ist unkonjugiert

Applikation: ELISA

Klon: 4D4

Produktdetails anti-RANKL Antikörper

Verwendungszweck: TRANCE/RANKL/TNFSF11 Monoclonal Antibody(Capture/Detector)

Aufreinigung: Protein A/G Purification

Immunogen: Recombinant Human TRANCE/RANKL/TNFSF11 protein expressed by E.coli

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA Capture 2-8 μg/mL,ELISA Detector 0.1-0.4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Konservierungsmittel: Without preservative

Handhabung: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Haltbarkeit: 12 months

Details zu RANKL

Target: RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))

Andere Bezeichnung: TRANCE/RANKL/TNFSF11

Hintergrund: CD254,TNFSF11,OPGL,RANKL,TRANCE,Tumor necrosis factor Ligand superfamiLy member 11,OsteocLast differentiation factor (ODF),Osteoprotegerin Ligand (OPGL),Receptor activator of nucLear factor kappa-B Ligand (RANKL),TNF-reLated activation-induced cytokine (TRANCE),Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells,chief among which is induction of long lasting oscillations in the intracellular concentration of Ca 2+ resulting in the activation of NFATC1,which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation,in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation.

UniProt: O14788

Pathways: NF-kappaB Signalweg