Frataxin Antikörper

Produktnummer ABIN7670612

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch Frataxin in ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Frataxin Antikörper (ABIN7670612)

Target: Frataxin (FXN)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Frataxin Antikörper ist unkonjugiert

Applikation: ELISA

Produktdetails anti-Frataxin Antikörper

Verwendungszweck: Frataxin/FXN Polyclonal Antibody

Aufreinigung: Antigen Affinity Purification

Immunogen: Recombinant Human Frataxin/FXN protein expressed by E.coli

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA Capture 2-8 μg/mL,ELISA Detector 0.1-0.4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Konservierungsmittel: Without preservative

Handhabung: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Haltbarkeit: 12 months

Details zu Frataxin

Target: Frataxin (FXN)

Andere Bezeichnung: Frataxin/FXN

Hintergrund: CyaY,d-FXN,FA,FARR,Frataxin mature form,Frataxin(81-210),FRDA,FRDA,Friedreich ataxia protein,Fxn,i-FXN,m56-FXN,m78-FXN,m81-FXN,MGC57199,X25,FXN,also named as FRDA,X25,m81-FXN,d-FXN,m78-FXN and i-FXN,belongs to the frataxin family. It promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe2+ to proteins involved in these pathways. FXN may play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe2+ to Fe3+, the oligomeric form but not the monomeric form has in vitro ferroxidase activity. FXN is cleaved to be 4 chains. FXN is expressed in the cytoplasm as a 210 amino acid (AA) precursor protein (pFXN, 23?KDa) that is translocated into mitochondria where it is processed by two consecutive steps into iFXN (FXN 42-210, 19?KDa) and finally mFXN (81-210, 14.2?KDa),which is functional.

UniProt: Q16595

Pathways: Transition Metal Ion Homeostasis, Regulation of Cell Size