Caspase 4 Antikörper

Produktnummer ABIN7670548

Dieses Anti-Caspase 4-Antikörper ist ein Ratte Monoklonal-Antikörper zur Detektion von Caspase 4 in ELISA (Capture). Geeignet für Human.

Kurzübersicht für Caspase 4 Antikörper (ABIN7670548)

Target: Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))

Reaktivität: Human

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser Caspase 4 Antikörper ist unkonjugiert

Applikation: ELISA (Capture)

Klon: 3A9

Produktdetails anti-Caspase 4 Antikörper

Verwendungszweck: Caspase-4 Monoclonal Antibody(Capture)

Aufreinigung: Protein A/G Purification

Immunogen: Recombinant Human Caspase-4 protein expressed by E.coli

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA Capture 2-8 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Konservierungsmittel: Without preservative

Handhabung: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Haltbarkeit: 12 months

Details zu Caspase 4

Target: Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))

Andere Bezeichnung: Caspase-4

Hintergrund: Caspase-4,CASP-4,ICE and Ced-3 homoLog 2,ICE(reL)-II,Mih1,Protease TX,CASP4,ICH2,Inflammatory caspase that acts as the effector of the non-canonical inflammasome by mediating lipopolysaccharide (lPS)-induced pyroptosis .Also indirectly activates the NlRP3 and NlRP6 inflammasomes. Acts as a thiol protease that cleaves a tetrapeptide after an Asp residue at position P1: catalyzes cleavage of CGAS,GSDMD and Il18 . Effector of the non-canonical inflammasome independently of NlRP3 inflammasome and CASP1: the non-canonical inflammasome promotes pyroptosis through GSDMD cleavage without involving secretion of cytokine Il1B and Il18 . In the non-canonical inflammasome,CASP4 is activated by direct binding to lPS without the need of an upstream sensor . lPS-binding promotes CASP4 activation and CASP4-mediated cleavage of GSDMD,followed by pyroptosis of infected cells and their extrusion into the gut lumen . Also indirectly promotes secretion of mature cytokines (Il1A,Il18 and HMGB1) downstream of GSDMD-mediated pyroptosis via activation of the NlRP3 and NlRP6 inflammasomes . Involved in NlRP3-dependent CASP1 activation and Il1B and Il18 secretion in response to non-canonical activators,such as UVB radiation or cholera enterotoxin . Involved in NlRP6 inflammasome-dependent activation in response to lipoteichoic acid (lTA),a cell-wall component of Gram-positive bacteria,which leads to CASP1 activation and Il1B and Il18 secretion . Involved in lPS-induced Il6 secretion,this activity may not require caspase enzymatic activity. The non-canonical inflammasome is required for innate immunity to cytosolic,but not vacuolar,bacteria. Plays a crucial role in the restriction of S.typhimurium replication in colonic epithelial cells during infection.

UniProt: P49662

Pathways: Apoptose, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity