ACE2 Antikörper

Produktnummer ABIN7670534

Dieses Ratte Monoklonal-Antikörper erkennt spezifisch ACE2 in ELISA (Detection). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für ACE2 Antikörper (ABIN7670534)

Target: ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

Reaktivität: Human

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser ACE2 Antikörper ist unkonjugiert

Applikation: ELISA (Detection)

Klon: 1G5

Produktdetails anti-ACE2 Antikörper

Verwendungszweck: ACE2 Monoclonal Antibody(Detector)

Aufreinigung: Protein A/G Purification

Immunogen: Recombinant Human ACE2 protein expressed by Mammalian

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: ELISA Detector 0.1-0.4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Konservierungsmittel: Without preservative

Handhabung: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Haltbarkeit: 12 months

Details zu ACE2

Target: ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

Andere Bezeichnung: ACE2

Hintergrund: ACEH,ACEII,ACE2 (Angiotensin-converting enzyme 2),also named as ACEH,is a zinc metalloprotease of the ACE family and a critical regulator of the reninangiotensin system. ACE2 has a more restricted tissue distribution than ACE,being found predominantly in the heart,kidneys,and testes although low levels have been detected in a variety of tissues. ACE2 has been shown to be a functional receptor of the human coronaviruses SARS-CoV and SARS-CoV-2. The expression level and expression pattern of human ACE2 in different tissues might be critical for the susceptibility,symptoms,and outcome of 2019-nCoV/SARS-CoV-2 infection. It can be used as a potential therapeutic target of SARS-CoV-2. The calculated molecular weight of ACE2 is 92 kDa but it migrates to 120 kDa due to N-glycosylation . Sometimes,several cleaved fragments can also be detected as 75 kDa,50 kDa or 37 kDa. It has 2 isoforms produced by alternative splicing. This antibody is specific to ACE2. The location of ACE2 is membrane and cytoplasm,however it accumulates in the nucleus during the mitosis.

UniProt: Q9BYF1

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour