ACE2 Antikörper

Produktnummer ABIN7670532

Der Kaninchen Polyklonal Anti-ACE2-Antikörper wurde für ELISA validiert. Er ist geeignet, ACE2 in Proben von Ratte zu detektieren.

Kurzübersicht für ACE2 Antikörper (ABIN7670532)

Target: ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ACE2 Antikörper ist unkonjugiert

Applikation: ELISA

Produktdetails anti-ACE2 Antikörper

Verwendungszweck: ACE2 Polyclonal Antibody(Capture/Detector)

Aufreinigung: Antigen Affinity Purification

Immunogen: Recombinant Rat ACE2 protein expressed by Mammalian

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA Capture 2-8 μg/mL,ELISA Detector 0.1-0.4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Konservierungsmittel: Without preservative

Handhabung: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Haltbarkeit: 12 months

Details zu ACE2

Target: ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

Andere Bezeichnung: ACE2

Hintergrund: ACEH,ACEII,ACE-2, also called ACEH (ACE homolog), is an integral membrane protein and a zinc metalloprotease of the ACE family that also includes somatic and germinal ACE . Human ACE-2 has about 40 % amino acid identity to the N- and C-terminal domains of human somatic ACE. The predicted human ACE-2 protein sequence consists of 805 amino acids, including a N-terminal signal peptide, a single catalytic domain, a C-terminal membrane anchor, and a short cytoplasmic tail. ACE-2 cleaves angiotensins I and II as a carboxypeptidase. ACE-2 Mrna is found at high levels in testis, kidney, and heart and at moderate levels in colon, small intestine, and ovary. Classical ACE inhibitors such as captopril and lisinopril do not inhibit ACE-2 activity. Novel peptide inhibitors of ACE-2 do not inhibit ACE activity. Genetic data from Drosophila, mice and rats show that ACE-2 is an essential regulator of heart function in vivo.

UniProt: Q5EGZ1

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour