ErbB2/Her2 Antikörper

Produktnummer ABIN8062509

Der Maus Monoklonal anti-ErbB2/Her2 Antikörper wird verwendet zum Nachweis von ErbB2/Her2 in Proben von Human. Er wurde validiert für FACS.

Kurzübersicht für ErbB2/Her2 Antikörper (ABIN8062509)

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ErbB2/Her2 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: ChA21

Produktdetails anti-ErbB2/Her2 Antikörper

Verwendungszweck: Purified Anti-Human CD340 Antibody[chA21]

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: ≥ 1 mg/mL

Buffer: Phosphate buffered solution, pH 7.2, containing 0.05 % proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: avoid freeze / thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Haltbarkeit: 12 months

Details zu ErbB2/Her2

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Andere Bezeichnung: CD340

Hintergrund: TKR,ERBB,erb-b2 receptor tyrosine kinase,Receptor tyrosine-protein kinase erbB,Tyrosine kinase-type cell surface receptor HER,HER2/ErbB,HER,MLN,ERBB2,CD340,HER-2,HER-2/neu,HER2,MLN 19,NEU,NGL,TKR1,erb-b2 receptor tyrosine kinase 2,HER2/ErbB2,MLN19,Metastatic lymph node gene 19 protein,p185,Proto-oncogene Neu,Receptor tyrosine-protein kinase erbB-2,Tyrosine kinase-type cell surface receptor HER2, Neu, erb-B2,CD340,erb-b2 receptor tyrosine kinase 2,HER2,HER-2,HER-2/neu,MLN 19,MLN19,NGL,TKR1,C erb B2/neu protein,CD340 antigen,Cerb B2/neu protein,CerbB2,ENV,ENVW,Erb b2 receptor tyrosine kinase 2,ERVWE1,HER 2,HER 2/NEU,Herstatin,HERV7Q,HERV-7q,HERVW,HERVWENV,HERV-W-ENV,Human epidermal growth factor receptor 2,NEU proto oncogene,neuro/glioblastoma derived oncogene homolog,neuro/glioblastoma derived oncogene homolog (avian),Neuroblastoma/glioblastoma derived oncogene homolog,p185erbB2,Proto-oncogene c-ErbB-2,Tyrosine kinase type cell surface receptor HER2,V erb b2 avian erythroblastic leukemia viral oncogene homolog 2,V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog),V erb b2 avian erythroblastic leukemia viral oncoprotein 2,V erb b2 erythroblastic leukemia viral oncogene homolog 2,Verb b2 erythroblastic leukemia viral oncogene homolog 2,ErbB2, also called Neu and Her2, is a transmembrane glycoprotein in the ErbB family of tyrosine kinase receptors for EGF superfamily growth factors. ErbB2 is widely expressed in epithelial cells and over-expressed in a large number of breast carcinomas. ErbB2 has no identified ligands but heterodimerizes with ErbB1/EGF R, ErbB3, or ErbB4 to form higher affinity signaling complexes. The protease ADAM10 releases a 110 kDa soluble fragment of ErbB2 from the cell surface. ErbB2 plays roles in development, cancer, communication at the neuromuscular junction, and regulation of cell growth and differentiation. The ErbB2/ErbB3 heterodimer is expressed in the majority of breast, skin, ovary and gastrointestinal tumors and transduces a highly mitogenic signal in response to neuregulin 1 (NRG1, heuregulin 1) or NRG2. ErbB3, ErbB2 and neuregulin are all required for formation of the sympathetic nervous system.

UniProt: P04626

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Skeletal Muscle Fiber Development