ABCB1 Antikörper

Produktnummer ABIN7669977

Dieses Maus Monoklonal-Antikörper erkennt spezifisch ABCB1 in FACS. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für ABCB1 Antikörper (ABIN7669977)

Target: ABCB1 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ABCB1 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: 15D3

Produktdetails anti-ABCB1 Antikörper

Verwendungszweck: Purified Anti-Human CD243 Antibody[15D3]

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: ≥ 1 mg/mL

Buffer: Phosphate buffered solution, pH 7.2, containing 0.05 % proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: avoid freeze / thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Haltbarkeit: 12 months

Details zu ABCB1

Target: ABCB1 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1))

Andere Bezeichnung: CD243

Hintergrund: MDR,PGY,ABC,ABCB,P-glycoprotein,Phospholipid transporter ABCB,ATP-dependent translocase ABCB,ATP-binding cassette sub-family B member,ABC20,CD243,CLCS,GP170,MDR1,P-GP,PGY1,P Glycoprotein,ABCB1,ATP-binding cassette sub-family B member 1,ATP-dependent translocase ABCB1,P-glycoprotein 1,Phospholipid transporter ABCB1,MDR-1, P-gp, gp170, ABC-B1,ATP binding cassette,Colchicin sensitivity,Doxorubicin resistance,member 1,Multidrug resistance 1,Multidrug resistance protein 1,P glycoprotein 1,P gp,sub family B (MDR/TAP),The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants.

UniProt: P08183