Rekombinanter TNFSF15 Antikörper

Produktnummer ABIN7661141

Der Maus Monoklonal Anti-TNFSF15-Antikörper wurde für IHC und IHC (fp) validiert. Er ist geeignet, TNFSF15 in Proben von Human zu detektieren.

Kurzübersicht für Rekombinanter TNFSF15 Antikörper (ABIN7661141)

Target: TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TNFSF15 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Klon: RVEGI-1283

Produktdetails anti-TNFSF15 Antikörper

Verwendungszweck: TNFS15 / VEGI (Vascular Endothelial Growth Inhibitor) (rVEGI/1283)

Produktmerkmale: VEGI is an anti-angiogenic cytokine that belongs to tumor necrosis factor superfamily, member 15 (TNFSF15). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of VEGI has been reported as a marker of poor prognosis in breast cancer.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant full-length human VEGI protein

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. Immunohistology (formalin): 1-2 μg/mL for 30 minutes at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris with 1 mM EDTA pH 9.0 for 10-20 minutes followed by cooling at RT for 20 minutes. Optimal dilution for a specific application should be determined by user

Kommentare:

Positive Control: Endothelial cells. Colon, intestine, placenta, lung, liver, kidney, pancreas, spleen and prostate.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, no BSA, no azide

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung:

Stable at room temperature or 37°C for 7 days.

Store at -20 °C. Protect fluorescent conjugates from light

Haltbarkeit: 24 months

Details zu TNFSF15

Target: TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))

Andere Bezeichnung: TNFS15

Hintergrund:

Synonyms: TNF ligand-related molecule 1 (TL1A), Tumor necrosis factor (ligand) superfamily member 15 (TNFSF15), Vascular endothelial growth inhibitor 192a, Vascular endothelial growth inhibitor (VEGI), VEGI192A

Gene Symbol: TNFSF15

Tissue Expression: Endothelial cells

Molekulargewicht: 22 kDa

Gen-ID: 9966

UniProt: O95150

Pathways: Positive Regulation of Endopeptidase Activity, Autophagie