Transferrin Receptor Antikörper (AA 94-212) (CF®647)

Produktnummer ABIN7661027

Der Maus Monoklonal Anti-Transferrin Receptor-Antikörper wurde für IHC und IHC (fp) validiert. Er ist geeignet, Transferrin Receptor in Proben von Human zu detektieren.

Kurzübersicht für Transferrin Receptor Antikörper (AA 94-212) (CF®647) (ABIN7661027)

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Transferrin Receptor Antikörper ist konjugiert mit CF®647

Applikation: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Klon: TFRC-1839

Produktdetails anti-Transferrin Receptor Antikörper (CF®647)

Bindungsspezifität: AA 94-212

Verwendungszweck: CD71 / Transferrin Receptor (TFRC) (Extracellular Domain) (TFRC/1839), CF647 conjugate

Produktmerkmale: This antibody recognizes a ~90-95 kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190 kDa. This MAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant extracellular fragment (around aa 94-212) of human TFRC protein

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Positive Control: Jurkat, HeLa, MCF-7 or K562 cells. Human placenta or Bone Marrow.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from light

Lagerung: 4 °C

Informationen zur Lagerung:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Haltbarkeit: 24 months

Details zu Transferrin Receptor

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Andere Bezeichnung: CD71

Hintergrund:

Synonyms: Mtvr-1, p90, TFR1, TFRC transferrin receptor (p90 CD71), TRFR

Gene Symbol: TFRC

Tissue Expression: Microvascular endothelial cells

Molekulargewicht: 85-95 kDa (monomer), 190 kDa (dimer)

Gen-ID: 7037

UniProt: P02786

Pathways: Transition Metal Ion Homeostasis