Transferrin Receptor Antikörper (CF®647)

Produktnummer ABIN7661026

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Transferrin Receptor in FACS. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Transferrin Receptor Antikörper (CF®647) (ABIN7661026)

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Transferrin Receptor Antikörper ist konjugiert mit CF®647

Applikation: Flow Cytometry (FACS)

Klon: TFRC-1396

Produktdetails anti-Transferrin Receptor Antikörper (CF®647)

Verwendungszweck: CD71 / Transferrin Receptor (TFRC)(TFRC/1396), CF647 conjugate

Produktmerkmale: Recognizes a ~90-95 kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190 kDa. This MAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant human TFRC protein

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Flow cytometry: 0.5-2 μg/million cells, Immunofluorescence: 1-2 μg/mL, Immunohistochemistry Frozen, 0.5-1.0 μg/mL, Optimal dilution for a specific application should be determined.. Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody

Kommentare:

Positive Control: PC3 cells. Human placenta or breast carcinoma.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from light

Lagerung: 4 °C

Informationen zur Lagerung:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Haltbarkeit: 24 months

Details zu Transferrin Receptor

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Andere Bezeichnung: CD71

Hintergrund:

Synonyms: Mtvr-1, p90, TFR1, TFRC transferrin receptor (p90 CD71), TRFR

Gene Symbol: TFRC

Tissue Expression: Microvascular endothelial cells

Molekulargewicht: 85-95 kDa (monomer), 190 kDa (dimer)

Gen-ID: 7037

UniProt: P02786

Pathways: Transition Metal Ion Homeostasis