Progesterone Receptor Antikörper (AA 483-571)

Produktnummer ABIN7658944

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Progesterone Receptor in IHC und IHC (fp). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Progesterone Receptor Antikörper (AA 483-571) (ABIN7658944)

Target: Progesterone Receptor (PGR)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Progesterone Receptor Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Klon: PGR-2694

Produktdetails anti-Progesterone Receptor Antikörper

Bindungsspezifität: AA 483-571

Verwendungszweck: Progesterone Receptor (Marker of Progestin Dependence)(PGR/2694)

Produktmerkmale: This MAb is specific to progesterone receptor and shows minimal cross-reaction with other members of the family. Progesterone receptor is expressed as two major isoforms, PR-A (81 kDa) and PR-B (116 kDa). Expression of PgR has been suggested to reflect a intact estrogen regulatory machinery and therefore, predict better clinical response to endocrine therapy than estrogen receptor (ER) alone. This MAb is excellent for immunohistochemical staining of formalin-fixed tissues. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant fragment of human Progesterone Receptor (PGR) protein (around aa 483-571)

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Positive Control: T47-D cells. Endometrial or Breast Carcinoma.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: PBS, 0.05 % BSA, 0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung:

Stable at room temperature or 37°C for 7 days.

Store at 2 to 8°C. Protect fluorescent conjugates from light

Haltbarkeit: 24 months

Details zu Progesterone Receptor

Target: Progesterone Receptor (PGR)

Andere Bezeichnung: Progesterone Receptor

Hintergrund:

Synonyms: NR3C3, Nuclear receptor subfamily 3 group C member 3, PGR, PR, PRA, PRB, Progesterone receptor form A, Progesterone receptor form B

Gene Symbol: PGR

Molekulargewicht: PR-A (81 kDa) and PR-B (116 kDa).

Gen-ID: 5241

UniProt: P06401

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Smooth Muscle Cell Migration