Nkx2-2 Antikörper (AA 1-119) (CF®640R)

Produktnummer ABIN7657937

Der Kaninchen Monoklonal Anti-Nkx2-2-Antikörper wurde für IHC und IHC (fp) validiert. Er ist geeignet, Nkx2-2 in Proben von Human zu detektieren.

Kurzübersicht für Nkx2-2 Antikörper (AA 1-119) (CF®640R) (ABIN7657937)

Target: Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Nkx2-2 Antikörper ist konjugiert mit CF®640R

Applikation: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Klon: NX2-2198R

Produktdetails anti-Nkx2-2 Antikörper (CF®640R)

Bindungsspezifität: AA 1-119

Verwendungszweck: NKX2.2 (Neuroendocrine & Ewing's Sarcoma Marker)(NX2/2198R), CF640R conjugate

Produktmerkmale: Expression of NKX2. 2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2. 2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93 % and a specificity of 89 %, and aids in the differential diagnosis of small round cell tumors. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant human NKX2.2 protein fragment (around aa1-119)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Positive Control: Pancreas or Ewing sarcoma

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from light

Lagerung: 4 °C

Informationen zur Lagerung:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Haltbarkeit: 24 months

Details zu Nkx2-2

Target: Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))

Andere Bezeichnung: NKX2.2

Hintergrund:

Synonyms: Homeobox protein NK-2 homolog B, NK2 transcription factor like protein B, NK2 transcription factor related locus 2, NKX22, Nkx2b, tinman

Gene Symbol: NKX2-2

Molekulargewicht: 40-50 kDa

Gen-ID: 4821

UniProt: O95096

Pathways: Dopaminergic Neurogenesis