Nkx2-2 Antikörper (N-Term)

Produktnummer ABIN2779575

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-Nkx2-2 Antikörper wird verwendet zum Nachweis von Nkx2-2 in Proben von Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Meerschweinchen, Pferd und Schaf. Er wurde validiert für IHC und WB.

Kurzübersicht für Nkx2-2 Antikörper (N-Term) (ABIN2779575)

Target: Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Meerschweinchen, Pferd, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Nkx2-2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB)

Produktdetails anti-Nkx2-2 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: NKX2-2 Antibody - N-terminal region

Sequenz: MSLTNTKTGF SVKDILDLPD TNDEEGSVAE GPEEENEGPE PAKRAGPLGQ

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Rabbit: 92%, Rat: 100%, Sheep: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against NKX2-2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human NKX2-2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP32338-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-Nkx2-2 Antikörper (ABIN2779575)

Owen, Kowalewski, Lessnick: "EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma." in: PLoS ONE, Vol. 3, Issue 4, pp. e1965, (2008) (PubMed).

Details zu Nkx2-2

Target: Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))

Andere Bezeichnung: NKX2-2

Hintergrund:

Background Information: Nkx2-2 contains 1 homeobox DNA-binding domain which is essential for interaction with OLIG2. Nkx2-2 may be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.

Gene Name: NK2 homeobox 2

Alternative Symbols: NKX2B, NKX2.2

Protein Name: Homeobox protein Nkx-2.2

Molekulargewicht: 30kDa

Gen-ID: 4821

NCBI Accession: NP_002500

UniProt: O95096

Pathways: Dopaminergic Neurogenesis