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Nkx2-2 Antikörper (N-Term)

Nkx2-2 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Meerschweinchen, Pferd, Schaf IHC, WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2779575
  • Target Alle Nkx2-2 Antikörper anzeigen
    Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))
    Bindungsspezifität
    • 17
    • 9
    • 7
    • 7
    • 7
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 106
    • 50
    • 43
    • 23
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    Human, Maus, Ratte, Rind (Kuh), Hund, Kaninchen, Meerschweinchen, Pferd, Schaf
    Wirt
    • 67
    • 49
    Kaninchen
    Klonalität
    • 64
    • 52
    Polyklonal
    Konjugat
    • 54
    • 11
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser Nkx2-2 Antikörper ist unkonjugiert
    Applikation
    • 50
    • 47
    • 38
    • 37
    • 30
    • 14
    • 13
    • 8
    • 7
    • 3
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB)
    Sequenz
    MSLTNTKTGF SVKDILDLPD TNDEEGSVAE GPEEENEGPE PAKRAGPLGQ
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Rabbit: 92%, Rat: 100%, Sheep: 100%
    Produktmerkmale
    This is a rabbit polyclonal antibody against NKX2-2. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human NKX2-2
    Top Product
    Discover our top product Nkx2-2 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 273 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Owen, Kowalewski, Lessnick: "EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma." in: PLoS ONE, Vol. 3, Issue 4, pp. e1965, (2008) (PubMed).

  • Target
    Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))
    Andere Bezeichnung
    NKX2-2 (Nkx2-2 Produkte)
    Synonyme
    XeNK-2 antikoerper, Xnkx2.2 antikoerper, nkx2-2-A antikoerper, nkx2.2 antikoerper, NKX-2.2 antikoerper, NKX2.2 antikoerper, NKX2B antikoerper, Nkx-2.2 antikoerper, Nkx2.2 antikoerper, tinman antikoerper, id:ibd5090 antikoerper, nk2.2 antikoerper, nkx2-2 antikoerper, wu:fc83b01 antikoerper, zgc:136536 antikoerper, NK2 homeobox 2 S homeolog antikoerper, NK2 homeobox 2 antikoerper, NK2 homeobox 2a antikoerper, nkx2-2.S antikoerper, NKX2-2 antikoerper, Nkx2-2 antikoerper, nkx2.2a antikoerper
    Hintergrund
    Nkx2-2 contains 1 homeobox DNA-binding domain which is essential for interaction with OLIG2. Nkx2-2 may be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.
    Alias Symbols: NKX2.2, NKX2B
    Protein Interaction Partner: Dlg4, SIN3A, HDAC1, OLIG2,
    Protein Size: 273
    Molekulargewicht
    30 kDa
    Gen-ID
    4821
    NCBI Accession
    NM_002509, NP_002500
    UniProt
    O95096
    Pathways
    Dopaminergic Neurogenesis
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