MUC16 Antikörper

Produktnummer ABIN7657358

Der Maus Monoklonal Anti-MUC16-Antikörper wurde für IHC und IHC (fp) validiert. Er ist geeignet, MUC16 in Proben von Human zu detektieren.

Kurzübersicht für MUC16 Antikörper (ABIN7657358)

Target: MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MUC16 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Klon: MUC16-1860

Produktdetails anti-MUC16 Antikörper

Verwendungszweck: MUC16 / CA125 (Ovarian Carcinoma Marker)(MUC16/1860)

Produktmerkmale: The mucins are a family of highly glycosylated, secreted proteins with a basic structure consisting of a variable number of tandem repeats (VNTRs). Membrane-associated and secretory Mucins are high molecular weight glycoproteins of the glycocalyx (polysaccharide biofilm) that protects mucosal epithelium from particulate matter and microorganisms. Epithelial Mucins are large, secreted and cell surface glycoproteins crucial for adhesion modulation, signaling and epithelial cell protection. The number of repeats is highly polymorphic and varies among different alleles. The Mucin family consists of Mucins 1-4, Mucin 5 (AC and B), Mucins 6-8, Mucins 11-13 and Mucins 15-17. The Mucin 16 protein (also commonly referred to as CA125), encoded for by the gene MUC16, is a very high molecular weight tumor antigen consisting of three domains: a carboxy terminal domain, an extracellular domain and an amino terminal domain. Mucin 16, an ovarian cancer-associated antigen, is used as a marker to monitor the progress of epithelial ovarian cancer. It is a hydrophilic membrane-associated protein that may be involved in vitamin A functions. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Full length native MUC16 protein Purified from human ovarian carcinoma

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Positive Control: MDA-MB-468 cells. Ovarian Cancer

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, no BSA, no azide

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung:

Stable at room temperature or 37°C for 7 days.

Store at -20 °C. Protect fluorescent conjugates from light

Haltbarkeit: 24 months

Details zu MUC16

Target: MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))

Andere Bezeichnung: CA125

Hintergrund:

Synonyms: CA125, Cancer antigen 125, MUC16, Mucin16, Ovarian cancer-related tumor marker CA125, Ovarian carcinoma antigen CA125

Gene Symbol: CA125

Molekulargewicht: >2,000 kDa

Gen-ID: 94025

UniProt: Q8WXI7