LSP1 Antikörper (AA 174-278)

Produktnummer ABIN7656443

Der Maus Monoklonal Anti-LSP1-Antikörper wurde für validiert. Er ist geeignet, LSP1 in Proben von Human zu detektieren.

Kurzübersicht für LSP1 Antikörper (AA 174-278) (ABIN7656443)

Target: LSP1 (Lymphocyte-Specific Protein 1 (LSP1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LSP1 Antikörper ist unkonjugiert

Applikation: Bitte anfragen

Klon: LSP1-3042

Produktdetails anti-LSP1 Antikörper

Bindungsspezifität: AA 174-278

Verwendungszweck: Lymphocyte Specific Protein 1 (LSP1) / pp52(LSP1/3042)

Produktmerkmale: LSP1 is a hematopoietic-expressed gene that encodes an F-actin-binding, leukocyte-specific (including B and T lymphocytes, granulocytes and macrophages), phosphoprotein. However, mRNA splice variants that do not encode the lympho-specific protein are expressed from this gene in nonlymphoid cell lines as well (myocytes, stromal cells and fibroblasts), suggesting pp52 has a divergent role in signal transduction. The pp52 (LSP1) locus maps to human chromosome 11p15. 5, which is implicated in tumor-related chromosomal translocations found in chronic lymphocytic leukemia. The pp52 promoter contains key elements that control transcriptional activity including an initiator specifying the unique 5' terminus of pp52 mRNA, tandem pairs of Ets and SP1 motifs, and a single C/EBP motif. LSP1 binds the cytoskeleton and has been implicated in affecting cytoskeletal remodeling in a variety of leukocyte functions, including cell motility and chemotaxis. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant fragment of human LSP1 protein (around aa174-278)

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: For coating for ELISA, order Ab without BSA. Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. Optimal dilution and staining procedure for a specific application should be determined by user. Recommended starting concentrations for titration are 1-2 μg/mL for most applications, or 1 μg/million cells/100 μLfor flow cytometry

Kommentare:

Positive Control: Human tonsil, colon, spleen or Hodgkin lymphoma (IHC-P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: PBS, 0.05 % BSA, 0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung:

Stable at room temperature or 37°C for 7 days.

Store at 2 to 8°C. Protect fluorescent conjugates from light

Haltbarkeit: 24 months

Details zu LSP1

Target: LSP1 (Lymphocyte-Specific Protein 1 (LSP1))

Andere Bezeichnung: Lymphocyte Specific Protein 1

Hintergrund:

Synonyms: WP34, pp52, lymphocyte specific protein 1, leukocyte specific protein 1

Gene Symbol: LSP1

Tissue Expression: Leukocytes

Molekulargewicht: 52 kDa

Gen-ID: 4046

UniProt: P33241