LSP1 Antikörper (AA 174-278)

Produktnummer ABIN6939969

Produktdetails anti-LSP1 Antikörper

Target: LSP1 (Lymphocyte-Specific Protein 1 (LSP1))

Bindungsspezifität: AA 174-278

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LSP1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Staining Methods (StM)

Aufreinigung: Purified by Protein A/G

Immunogen: Recombinant fragment of human LSP1 protein (around aa174-278) (exact sequence is proprietary)

Klon: LSP1-3025

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: Human tonsil, colon, spleen or Hodgkin's lymphoma (IHC-P).

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu LSP1

Target: LSP1 (Lymphocyte-Specific Protein 1 (LSP1))

Andere Bezeichnung: LSP1 (LSP1 Produkte)

Synonyme: LSP1 antikoerper, Lsp-1 antikoerper, WP34 antikoerper, p50 antikoerper, pp52 antikoerper, lymphocyte-specific protein 1 antikoerper, lymphocyte-specific protein 1 L homeolog antikoerper, lymphocyte specific 1 antikoerper, LSP1 antikoerper, lsp1.L antikoerper, Lsp1 antikoerper

Hintergrund: LSP1 is a hematopoietic-expressed gene that encodes an F-actin-binding, leukocyte-specific (including B and T lymphocytes, granulocytes and macrophages), phosphoprotein. However, mRNA splice variants that do not encode the lympho-specific protein are expressed from this gene in nonlymphoid cell lines as well (myocytes, stromal cells and fibroblasts), suggesting pp52 has a divergent role in signal transduction. The pp52 (LSP1) locus maps to human chromosome 11p15.5, which is implicated in tumor-related chromosomal translocations found in chronic lymphocytic leukemia. The pp52 promoter contains key elements that control transcriptional activity including an initiator specifying the unique 5' terminus of pp52 mRNA, tandem pairs of Ets and SP1 motifs, and a single C/EBP motif. LSP1 binds the cytoskeleton and has been implicated in affecting cytoskeletal remodeling in a variety of leukocyte functions, including cell motility and chemotaxis.

Molekulargewicht: 52kDa

Gen-ID: 4046

UniProt: P33241