Cathepsin D Antikörper (AA 104-250) (CF®740)

Produktnummer ABIN7650666

Dieses Anti-Cathepsin D-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Cathepsin D in WB, IHC und IHC (fp). Geeignet für Human.

Kurzübersicht für Cathepsin D Antikörper (AA 104-250) (CF®740) (ABIN7650666)

Target: Cathepsin D (CTSD)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Cathepsin D Antikörper ist konjugiert mit CF®740

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Klon: CTSD-3082

Produktdetails anti-Cathepsin D Antikörper (CF®740)

Bindungsspezifität: AA 104-250

Verwendungszweck: Cathepsin D (Tumor Marker)(CTSD/3082), CF740 conjugate

Produktmerkmale: Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 43 kDa preprocathepsin D that is cleaved and glycosylated to form a 46 kDa procathepsin D and then further cleaved to produce 28 kDa and 15 kDa subunits (heavy and light chains, respectively). Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant fragment of human Cathepsin D protein (around aa 104-250)

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Positive Control: K-562, A431 or SK-BR3 cells. Kidney, Liver, Lung or Breast.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % rBSA, 0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from light

Lagerung: 4 °C

Informationen zur Lagerung:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Haltbarkeit: 24 months

Details zu Cathepsin D

Target: Cathepsin D (CTSD)

Andere Bezeichnung: Cathepsin D

Hintergrund:

Synonyms: Cathepsin D, CTSD, Lysosomal aspartyl peptidase

Gene Symbol: CTSD

Molekulargewicht: 46 kDa (Procathepsin D), 28 kDa (Cathepsin D)

Gen-ID: 1509

UniProt: P07339

Pathways: Peptide Hormone Metabolism