Calcineurin B Antikörper (CF®405S)

Produktnummer ABIN7650378

Dieses Anti-Calcineurin B-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Calcineurin B in IHC und IHC (fp). Geeignet für Human.

Kurzübersicht für Calcineurin B Antikörper (CF®405S) (ABIN7650378)

Target: Calcineurin B (CAN)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Calcineurin B Antikörper ist konjugiert mit CF®405S

Applikation: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Klon: CALNB-2342

Produktdetails anti-Calcineurin B Antikörper (CF®405S)

Verwendungszweck: Calcineurin B / PPP3R1(CALNB/2342), CF405S conjugate

Produktmerkmale: This antibody recognizes the Calcineurin B alpha protein, encoded by the PPP3R1 (Protein Phosphatase 3 Regulatory Subunit B Alpha) gene. Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59 kDa catalytic A subunit and a 19 kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant full-length Calcineurin B protein

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Positive Control: HeLa, MCF-7 or A431 cells. Prostate, Thyroid or Pancreas.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from light

Lagerung: 4 °C

Informationen zur Lagerung:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Haltbarkeit: 24 months

Details zu Calcineurin B

Target: Calcineurin B (CAN)

Andere Bezeichnung: Calcineurin B

Hintergrund:

Synonyms: Calcineurin B, Calcineurin subunit B type 1, Protein Phosphatase 3 Regulatory Subunit B Alpha, CALNB1, Cna2, CNB, CNB1, PPP3R1

Gene Symbol: PPP3R1

Tissue Expression: Brain|T-cells

Molekulargewicht: 19 kDa

Gen-ID: 5534

UniProt: P63098

Pathways: Cellular Glucan Metabolic Process, VEGF Signaling