C5 Antikörper (AA 701-755) (Biotin)

Produktnummer ABIN727877

Der Kaninchen Polyklonal Anti-C5-Antikörper wurde für WB, ELISA und IHC (p) validiert. Er ist geeignet, C5 in Proben von Human und Maus zu detektieren.

Kurzübersicht für C5 Antikörper (AA 701-755) (Biotin) (ABIN727877)

Target: C5 (Complement Component 5 (C5))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C5 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-C5 Antikörper (Biotin)

Bindungsspezifität: AA 701-755

Kreuzreaktivität: Human, Maus

Homologie: Rat

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse C5a (725-770aa)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu C5

Target: C5 (Complement Component 5 (C5))

Andere Bezeichnung: C5a anaphylatoxin

Hintergrund:

Synonyms: C5, He, C5a, Complement C5, Hemolytic complement, Hc

Background: Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.

Gen-ID: 15139

UniProt: P06684

Pathways: Komplementsystem, Carbohydrate Homeostasis