Tissue factor Antikörper (Biotin)

Produktnummer ABIN7608086

Der Human-Chimeric Anti-Tissue factor-Antikörper wurde für FACS validiert. Er ist geeignet zum Nachweis von Tissue factor in Proben aus Human. }

Kurzübersicht für Tissue factor Antikörper (Biotin) (ABIN7608086)

Target: Tissue factor (F3) (Coagulation Factor III (thromboplastin, Tissue Factor) (F3))

Reaktivität: Human

Wirt: Human, Kaninchen

Klonalität: Chimeric

Konjugat: Dieser Tissue factor Antikörper ist konjugiert mit Biotin

Applikation: Flow Cytometry (FACS)

Klon: DMC463

Produktdetails anti-Tissue factor Antikörper (Biotin)

Verwendungszweck: Biotinylated Anti-CD142 antibody(DMC463), IgG1 Chimeric mAb

Aufreinigung: Purified from cell culture supernatant by affinity chromatography

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow Cyt 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Details zu Tissue factor

Target: Tissue factor (F3) (Coagulation Factor III (thromboplastin, Tissue Factor) (F3))

Andere Bezeichnung: CD142

Hintergrund: This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces, for example, on monocytes. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Platelets and monocytes have been shown to express this coagulation factor under procoagulatory and proinflammatory stimuli, and a major role in HIV-associated coagulopathy has been described. Platelet-dependent monocyte expression of coagulation factor III has been described to be associated with Coronavirus Disease 2019 (COVID-19) severity and mortality. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Aug 2020]

UniProt: P13726

Pathways: Positive Regulation of Endopeptidase Activity, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling