Cathepsin L Antikörper (Middle Region)

Produktnummer ABIN7603031

Dieses Anti-Cathepsin L-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Cathepsin L in WB. Geeignet für Human und Maus.

Kurzübersicht für Cathepsin L Antikörper (Middle Region) (ABIN7603031)

Target: Cathepsin L (CTSL1) (Cathepsin L1 (CTSL1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cathepsin L Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Cathepsin L Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: Anti-Cathepsin L/MEP/CTSL Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-Cathepsin L/MEP/CTSL Antibody Picoband® (ABIN7603031). Tested in WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human Cathepsin L/MEP/CTSL, which shares 61.1% amino acid (aa) sequence identity with rat CTSL.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human, Mouse
1. Abudula, A., Rommerskirch, W., Weber, E., Gunther, D., Wiederanders, B. Splice variants of human cathepsin L mRNA show different expression rates. Biol. Chem. 382: 1583-1591, 2001. 2. Arora, S., Chauhan, S. S. Identification and characterization of a novel human cathepsin L splice variant. Gene 293: 123-131, 2002. 3. Bakhshi, R., Goel, A., Seth, P., Chhikara, P., Chauhan, S. S. Cloning and characterization of human cathepsin L promoter. Gene 275: 93-101, 2001.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu Cathepsin L

Target: Cathepsin L (CTSL1) (Cathepsin L1 (CTSL1))

Andere Bezeichnung: CTSL

Hintergrund:

Synonyms: Neutrophil cytosol factor 1, NCF-1, 47 kDa autosomal chronic granulomatous disease protein, 47 kDa neutrophil oxidase factor, NCF-47K, Neutrophil NADPH oxidase factor 1, Nox organizer 2, Nox-organizing protein 2, SH3 and PX domain-containing protein 1A, p47-phox, NCF1, NOXO2, SH3PXD1A

Tissue Specificity: Detected in peripheral blood monocytes and neutrophils (at protein level).

Background: The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell.

Molekulargewicht: 37 kDa

Gen-ID: 1514

UniProt: P07711

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades