Cathepsin S Antikörper (C-Term)

Produktnummer ABIN7602873

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Cathepsin S in WB und FACS. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Cathepsin S Antikörper (C-Term) (ABIN7602873)

Target: Cathepsin S (CTSS)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cathepsin S Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Produktdetails anti-Cathepsin S Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: Anti-CTSS Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-CTSS Antibody Picoband® (ABIN7602873). Tested in WB, Flow Cytometry applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human CTSS.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
1. Deussing, J., Roth, W., Rommerskirch, W., Wiederanders, B., von Figura, K., Peters, C. The genes of the lysosomal cysteine proteinases cathepsin B, H, L, and S map to different mouse chromosomes. Mammalian Genome 8: 241-245, 1997. 2. Driessen, C., Bryant, R. A., Lennon-Dumenil, A. M., Villadangos, J. A., Bryant, P. W., Shi, G. P., Chapman, H. A., Ploegh, H. L. Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells. J. Cell Biol. 147: 775-790, 1999. 3. Gelb, B. D., Shi, G.-P., Heller, M., Weremowicz, S., Morton, C., Desnick, R. J., Chapman, H. A. Structure and chromosomal assignment of the human cathepsin K gene. Genomics 41: 258-262, 1997.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu Cathepsin S

Target: Cathepsin S (CTSS)

Andere Bezeichnung: CTSS

Hintergrund:

Synonyms: CTSS, Cathepsin S, EC 3.4.22.27

Background: The preproprotein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that participates in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The mature protein cleaves the invariant chain of MHC class II molecules in endolysosomal compartments and enables the formation of antigen-MHC class II complexes and the proper display of extracellular antigenic peptides by MHC-II. The mature protein also functions as an elastase over a broad pH range. When secreted from cells, this protein can remodel components of the extracellular matrix such as elastin, collagen, and fibronectin. This gene is implicated in the pathology of many inflammatory and autoimmune diseases and, given its elastase activity, plays a significant role in some pulmonary diseases. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Molekulargewicht: 25 kDa

Gen-ID: 1520

UniProt: P25774

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades