CCR1 Antikörper (C-Term)

Produktnummer ABIN7602861

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch CCR1 in WB. Er zeigt eine Reaktivität gegenüber Maus und Ratte.

Kurzübersicht für CCR1 Antikörper (C-Term) (ABIN7602861)

Target: CCR1 (Chemokine (C-C Motif) Receptor 1 (CCR1))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CCR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CCR1 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: Anti-CCR1 Antibody Picoband®

Produktmerkmale: Anti-CCR1 Antibody Picoband® (ABIN7602861). Tested in WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of mouse CCR1, which shares 73.7% amino acid (aa) sequence identity with human CCR1, respectively.

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Mouse, Rat
1. Charo, I. F., Ransohoff, R. M. The many roles of chemokines and chemokine receptors in inflammation. New Eng. J. Med. 354: 610-621, 2006. 2. Daugherty, B. L., Springer, M. S. The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21. Genomics 41: 294-295, 1997. 3. Gao, J.-L., Kuhns, D. B., Tiffany, H. L., McDermott, D., Li, X., Francke, U., Murphy, P. M. Structure and functional expression of the human macrophage inflammatory protein 1-alpha/RANTES receptor. J. Exp. Med. 177: 1421-1427, 1993.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu CCR1

Target: CCR1 (Chemokine (C-C Motif) Receptor 1 (CCR1))

Andere Bezeichnung: CCR1

Hintergrund: C-C chemokine receptor type 1 is a protein that in humans is encoded by the CCR1 gene. This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p.

Molekulargewicht: 41 kDa

Gen-ID: 12768

UniProt: P51675