JAG1 Antikörper (AA 994-1218)

Produktnummer ABIN7602727

Der Kaninchen Polyklonal Anti-JAG1-Antikörper wurde für WB, ELISA und FACS validiert. Er ist geeignet, JAG1 in Proben von Human zu detektieren.

Kurzübersicht für JAG1 Antikörper (AA 994-1218) (ABIN7602727)

Target: JAG1 (Jagged 1 (JAG1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser JAG1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-JAG1 Antikörper

Bindungsspezifität: AA 994-1218

Verwendungszweck: Anti-Jagged1/JAG1 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-Jagged1/JAG1 Antibody Picoband® (ABIN7602727). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human Jagged1/JAG1 recombinant protein (Position: A994-V1218).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Bauer, R. C., Laney, A. O., Smith, R., Gerfen, J., Morrissette, J. J. D., Woyciechowski, S., Garbarini, J., Loomes, K. M., Krantz, I. D., Urban, Z., Gelb, B. D., Goldmuntz, E., Spinner, N. B. Jagged1 (JAG1) mutations in patients with tetralogy of Fallot or pulmonic stenosis. Hum. Mutat. 31: 594-601, 2010. 2. Bell, S. E., Mavila, A., Salazar, R., Bayless, K. J., Kanagala, S., Maxwell, S. A., Davis, G. E. Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling. J. Cell Sci. 114: 2755-2773, 2001. 3. Boyer, J., Crosnier, C., Driancourt, C., Raynaud, N., Gonzales, M., Hadchouel, M., Meunier-Rotival, M. Expression of mutant JAGGED1 alleles in patients with Alagille syndrome. Hum. Genet. 116: 445-453, 2005.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu JAG1

Target: JAG1 (Jagged 1 (JAG1))

Andere Bezeichnung: JAG1

Hintergrund:

Synonyms: Plasminogen activator inhibitor 1, PAI, PAI-1, Endothelial plasminogen activator inhibitor, Serpin E1, Serpine1, Pai1, Planh1

Tissue Specificity: Ubiquitous.

Background: The JAG1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter is involved in signaling processes. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.

Molekulargewicht: 180 kDa

Gen-ID: 182

UniProt: P78504

Pathways: Notch Signalweg, Stem Cell Maintenance