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NT5DC2 Antikörper (AA 9-520)

Der Kaninchen Polyklonal Anti-NT5DC2-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, NT5DC2 in Proben von Human zu detektieren.
Produktnummer ABIN7602634

Kurzübersicht für NT5DC2 Antikörper (AA 9-520) (ABIN7602634)

Target

NT5DC2 (5'-Nucleotidase Domain Containing 2 (NT5DC2))

Reaktivität

  • 11
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 11
Kaninchen

Klonalität

  • 11
Polyklonal

Konjugat

  • 6
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser NT5DC2 Antikörper ist unkonjugiert

Applikation

Western Blotting (WB), ELISA
  • Bindungsspezifität

    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 9-520

    Verwendungszweck

    Anti-NT5DC2 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-NT5DC2 Antibody Picoband® (ABIN7602634). Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human NT5DC2 recombinant protein (Position: Q9-R520).

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.25-0.5 μg/mL, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Zhu, Z. , Hou, Q. , & Guo, H. . (2020). Nt5dc2 knockdown inhibits colorectal carcinoma progression by repressing metastasis, angiogenesis and tumor-associated macrophage recruitment: a mechanism involving vegf signaling. Experimental Cell Research, 397( 1). 2. A, X. J. , B, X. L. , C, Z. Z. , & A, L. X. . (2020). Nt5dc2 suppression restrains progression towards metastasis of non-small-cell lung cancer through regulation p53 signaling. Biochemical and Biophysical Research Communications, 533( 3), 354-361. 3. Li, K. S. , Zhu, X. D. , Liu, H. D. , Zhang, S. Z. , & Sun, H. C. . (2020). Nt5dc2 promotes tumor cell proliferation by stabilizing egfr in hepatocellular carcinoma. Cell Death & Disease, 11(5).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target

    NT5DC2 (5'-Nucleotidase Domain Containing 2 (NT5DC2))

    Andere Bezeichnung

    NT5DC2

    Hintergrund

    Synonyms: Kelch repeat and BTB domain-containing protein 2, BTB and kelch domain-containing protein 1, KBTBD2, BKLHD1, KIAA1489

    Tissue Specificity: Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

    Background: 5'-Nucleotidase domain containing 2 (NT5DC2) is a member of the NT5DC family and contains a haloacid dehalogenase motif localized in the N-terminus of these proteins. NT5DC2 shows high sequence similarity with NT5C2. NT5C2 has received attention in the field of hematological neoplasms because NT5C2 mutations have been demonstrated to drive resistance to thiopurine, a drug frequently used to treat hematological neoplasms. NT5C2 catalyzes purine-nucleotide metabolism and induces chemotherapeutic resistance via excess export of purines to the extracellular space and depletion of the intracellular purine-nucleotide pool. Therefore, NT5DC2 may also participate in purine-nucleotide metabolism and exert purine-nucleotide catalytic activity. NT5DC2 overexpression promotes HCC cell proliferation and clone formation by regulating the cell cycle and promoting tumor growth in subcutaneous xenografts, while NT5DC2 knockdown inhibits these processes. NT5DC2 is associated with attention-deficit/hyperactivity disorder and bipolar disorder. NT5DC2 interacts with tyrosine hydroxylase (TH) to regulate TH catalytic activity and thus regulate catecholamine synthesis. NT5DC2 has been shown to interact with and stabilize Fyn, an Src family proto-oncogene, and plays a role in regulating glioblastoma progression.

    Molekulargewicht

    61 kDa

    Gen-ID

    64943

    UniProt

    Q9H857
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