ATF6 Antikörper (AA 79-670)

Produktnummer ABIN7602466

Der Kaninchen Polyklonal Anti-ATF6-Antikörper wurde für WB, ELISA, IF, ICC und FACS validiert. Er ist geeignet, ATF6 in Proben von Human zu detektieren.

Kurzübersicht für ATF6 Antikörper (AA 79-670) (ABIN7602466)

Target: ATF6 (Activating Transcription Factor 6 (ATF6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATF6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Produktdetails anti-ATF6 Antikörper

Bindungsspezifität: AA 79-670

Verwendungszweck: Anti-ATF6 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-ATF6 Antibody Picoband® (ABIN7602466). Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human ATF6 recombinant protein (Position: Q79-Q670).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Li, M., Baumeister, P., Roy, B., Phan, T., Foti, D., Luo, S., Lee, A. S. : ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1. Molec. Cell. Biol. 20: 5096-5106, 2000. 2. Thameem, F., Farook, V. S., Bogardus, C., Prochazka, M. : Association of amino acid variants in the activating transcription factor 6 gene (ATF6) on 1q21-q23 with type 2 diabetes in Pima Indians. Diabetes 55: 839-842, 2006.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu ATF6

Target: ATF6 (Activating Transcription Factor 6 (ATF6))

Andere Bezeichnung: ATF6

Hintergrund:

Synonyms: Cyclic AMP-dependent transcription factor ATF-6 alpha,cAMP-dependent transcription factor ATF-6 alpha,Activating transcription factor 6 alpha,ATF6-alpha,Processed cyclic AMP-dependent transcription factor ATF-6 alpha,ATF6,

Tissue Specificity: Ubiquitous.

Background: ATF6, a member of the leucine zipper protein family, is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules. This gene is mapped to chromosome 1q23.3. ATF6 can constitutively induce the promoter of glucose-regulated protein (grp) genes through activation of the endoplasmic reticulum (ER) stress element (ERSE).

Molekulargewicht: 90-100 kDa

Gen-ID: 22926

UniProt: P18850

Pathways: ER-Nucleus Signaling, Unfolded Protein Response