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METRNL Antikörper (AA 66-311)

METRNL Reaktivität: Human ELISA, WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7602241
  • Target Alle METRNL Antikörper anzeigen
    METRNL (Meteorin, Glial Cell Differentiation Regulator-Like (METRNL))
    Bindungsspezifität
    • 15
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 66-311
    Reaktivität
    • 14
    • 11
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Human
    Wirt
    • 20
    • 2
    Kaninchen
    Klonalität
    • 22
    Polyklonal
    Konjugat
    • 14
    • 4
    • 2
    • 2
    Dieser METRNL Antikörper ist unkonjugiert
    Applikation
    • 12
    • 12
    • 5
    ELISA, Western Blotting (WB)
    Verwendungszweck
    Anti-METRNL Antibody Picoband®
    Produktmerkmale
    Anti-METRNL Antibody Picoband® (ABIN7602241). Tested in WB, ELISA applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    E.coli-derived human METRNL recombinant protein (Position: K66-D311). Human METRNL shares 78.5% and 79.3% amino acid (aa) sequence identity with mouse and rat METRNL, respectively.
    Top Product
    Discover our top product METRNL Primärantikörper
  • Applikationshinweise
    Western blot, 0.25-0.5 μg/mL, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Hartz, P. A. Personal Communication. Baltimore, Md. 2/24/2015. 2. Li, Z.-Y., Zheng, S.-L., Wang, P., Xu, T.-Y., Guan, Y.-F., Zhang, Y.-J., Miao, C.-Y. Subfatin is a novel adipokine and unlike meteorin in adipose and brain expression. CNS Neurosci. Ther. 20: 344-354, 2014. 3. Rao, R. R., Long, J. Z., White, J. P., Svensson, K. J., Lou, J., Lokurkar, I., Jedrychowski, M. P., Ruas, J. L., Wrann, C. D., Lo, J. C., Camera, D. M., Lachey, J., Gygi, S., Seehra, J., Hawley, J. A., Spiegelman, B. M. Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell 157: 1279-1291, 2014.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target
    METRNL (Meteorin, Glial Cell Differentiation Regulator-Like (METRNL))
    Andere Bezeichnung
    METRNL (METRNL Produkte)
    Hintergrund
    Meteorin-like/Meteorin-Beta (Metrnl)/IL-41, also known as subfatin and cometin, is a small (~27 kDa) secreted cytokine, protein encoded by a gene called meteorin-like (METRNL). Meteorin-like protein (METRNL) is a 311 amino acid (aa) protein that shows 45 % homology with Meteorin (in mouse). Meteorin itself is a secreted 30 kDa protein that is expressed in glial and neuronal cells and their precursors during development and in the adult. In the adult Meteorin is primarily expressed by astrocytes. Meteorin promotes neurite outgrowth, glial cell differentiation, and neuronal survival following excitotoxic injury. It also inhibits sprouting angiogenesis and promotes blood vessel maturation. Mouse Meteorin?like protein is synthesized with a 45 amino acid (aa) signal peptide and is selectively expressed in the otic vesicle during inner ear development. Mature mouse Meteorin?like protein shares 79 % and 98 % aa sequence identity with human and rat Meteorin?like protein, respectively. Alternate splicing generates an additional isoform that lacks the N?terminal 82 amino acids including the signal peptide. The promoter region of the METRNL gene contains a recognition site for the Pax2, Pax5, and Pax8 transcription factors, and Pax2 binds specifically to this region. METRNL is the only gene found within the terminus of the human chromosome 17 q?arm which can be deleted in the rare Ring 17 syndrome.
    Molekulargewicht
    34 kDa
    Gen-ID
    284207
    UniProt
    Q641Q3
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