METRNL Antikörper (AA 46-311)

Produktnummer ABIN7177465

Der Kaninchen Polyklonal anti-METRNL Antikörper (ABIN7177465) detektiert spezifisch METRNL in ELISA und WB. Dieser Antikörper reagiert spezifisch mit Proben aus Maus.

Kurzübersicht für METRNL Antikörper (AA 46-311) (ABIN7177465)

Target: METRNL (Meteorin, Glial Cell Differentiation Regulator-Like (METRNL))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser METRNL Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Produktdetails anti-METRNL Antikörper

Bindungsspezifität: AA 46-311

Verwendungszweck: Metrnl Antibody

Kreuzreaktivität: Ratte

Aufreinigung: Protein G purified

Reinheit: >95 %

Immunogen: Recombinant Mouse Meteorin-like protein (46-311AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu METRNL

Target: METRNL (Meteorin, Glial Cell Differentiation Regulator-Like (METRNL))

Andere Bezeichnung: Metrnl

Hintergrund:

Background: Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures.

Aliases: MetrnlMeteorin-like protein antibody, Subfatin antibody

UniProt: Q8VE43