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MUS81 Antikörper (AA 6-545)

Der Kaninchen Polyklonal Anti-MUS81-Antikörper wurde für ELISA, WB und FACS validiert. Er ist geeignet, MUS81 in Proben von Human und Ratte zu detektieren.
Produktnummer ABIN7602139

Kurzübersicht für MUS81 Antikörper (AA 6-545) (ABIN7602139)

Target

Alle MUS81 Antikörper anzeigen
MUS81 (MUS81 Endonuclease Homolog (MUS81))

Reaktivität

  • 18
  • 7
  • 5
  • 2
  • 2
  • 1
Human, Ratte

Wirt

  • 17
  • 1
Kaninchen

Klonalität

  • 18
Polyklonal

Konjugat

  • 14
  • 2
  • 1
  • 1
Dieser MUS81 Antikörper ist unkonjugiert

Applikation

  • 11
  • 7
  • 5
  • 4
  • 1
ELISA, Western Blotting (WB), Flow Cytometry (FACS)
  • Bindungsspezifität

    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 6-545

    Verwendungszweck

    Anti-MUS81 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-MUS81 Antibody Picoband® (ABIN7602139). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human MUS81 recombinant protein (Position: R6-C545).

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.25-0.5 μg/mL, Rat
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Chen, X.-B., Melchionna, R., Denis, C.-M., Gaillard, P.-H. L., Blasina, A., Van de Weyer, I., Boddy, M. N., Russell, P., Vialard, J., McGowan, C. H. Human Mus81-associated endonuclease cleaves Holliday junctions in vitro. Molec. Cell 8: 1117-1127, 2001. 2. Ciccia, A., Constantinou, A., West, S. C. Identification and characterization of the human Mus81-Eme1 endonuclease. J. Biol. Chem. 278: 25172-25178, 2003. 3. Ciccia, A., Ling, C., Coulthard, R., Yan, Z., Xue, Y., Meetei, A. R., Laghmani, E. H., Joenje, H., McDonald, N., de Winter, J. P., Wang, W., West, S. C. Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM. Molec. Cell 25: 331-343, 2007.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target

    MUS81 (MUS81 Endonuclease Homolog (MUS81))

    Andere Bezeichnung

    MUS81

    Hintergrund

    Synonyms: Lipopolysaccharide-binding protein, LBP, Lbp,

    Tissue Specificity: Detected in blood serum (at protein level).

    Background: Crossover junction endonuclease MUS81 is an enzyme that in humans is encoded by the MUS81 gene. This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks.

    Molekulargewicht

    70 kDa

    Gen-ID

    80198

    Pathways

    DNA Reparatur
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