Netrin 3 Antikörper (AA 51-473)

Produktnummer ABIN7601935

Der Kaninchen Polyklonal Anti-Netrin 3-Antikörper wurde für WB, ELISA, IHC, ICC und IF validiert. Er ist geeignet, Netrin 3 in Proben von Human und Ratte zu detektieren.

Kurzübersicht für Netrin 3 Antikörper (AA 51-473) (ABIN7601935)

Target: Netrin 3 (Ntn3)

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Netrin 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Produktdetails anti-Netrin 3 Antikörper

Bindungsspezifität: AA 51-473

Verwendungszweck: Anti-NTN3 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-NTN3 Antibody Picoband® (ABIN7601935). Tested in ELISA, IF, IHC, ICC, WB, Flow Cytometry (Intracellular) applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human NTN3 recombinant protein (Position: R51-R473).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human, Rat
Immunohistochemistry, 2-5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Van Raay, T. J., Foskett, S. M., Connors, T. D., Klinger, K. W., Landes, G. M., Burn, T. C. The NTN2L gene encoding a novel human netrin maps to the autosomal dominant polycystic kidney disease region on chromosome 16p13.3. Genomics 41: 279-282, 1997.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu Netrin 3

Target: Netrin 3 (Ntn3)

Andere Bezeichnung: NTN3

Hintergrund:

Synonyms: Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1, PYROXD1

Tissue Specificity: Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Background: Netrins are a family of highly conserved proteins responsible for axon guidance and cell movement throughout neural development. Netrins can be divided into secreted netrins (netrin 1,3,4 and 5) and membrane-tethered glycophosphatidylinositol (GPI)-linked netrins (netrin G1 and G2).Secreted netrins carry their function via interaction with several receptors that include the deleted in colorectal (DCC) family, and the uncoordinated-5 (UNC5-A through UNC5-D) family.Netrin-3 was discovered in 1997 using sequence homology searching of netrin-2. Similarly to other netrins, Netrin-3 plays an important role in the development of the nervous system. Netrin-3 structure consist of a laminin-like domain located on the N-terminal, three epidermal growth factors like repeats (EGF), and a C-terminal netrin-like domain (NTR). Mutations in NTN3, the gene encoding netrin-3 was found to be associated with the development of several carcinomas.

Molekulargewicht: 70 kDa

Gen-ID: 4917

UniProt: O00634

Pathways: Regulation of Muscle Cell Differentiation