Der Kaninchen-Polyklonal Anti-RNASE1-Antikörper wurde für WB, ELISA und FACS validiert. Er ist geeignet zum Nachweis von RNASE1 in Proben aus Human, Maus und Ratte.
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Anti-RNASE1 Antibody (ABIN7601896). Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.
Aufreinigung
Immunogen affinity purified.
Immunogen
E.coli-derived human RNASE1 recombinant protein (Position: S50-T156). Human RNASE1 shares 71.8% and 68% amino acid (aa) sequence identity with mouse and rat RNASE1, respectively.
At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
Target
RNASE1
(Ribonuclease, RNase A Family, 1 (Pancreatic) (RNASE1))
Andere Bezeichnung
RNASE1
Hintergrund
RIBONUCLEASE A FAMILY, 1(Ribonuclease pancreatic) is an enzyme that in humans is encoded by the RNASE1 gene. By genomic sequence analysis, RNASE1 gene is mapped the to chromosome 14q11.2, where it is linked to 7 other RNase A superfamily genes. Monomeric human pancreatic RNase, devoid of any biological activity other than its RNA degrading ability, was engineered into a dimeric protein with a cytotoxic action on mouse and human tumor cells, but lacking any appreciable toxicity on mouse and human normal cells. This dimeric variant of human pancreas RNase selectively sensitizes to apoptotic death cells derived from a human thyroid tumor. Because of its selectivity for tumor cells, and because of its human origin, this protein represents a potentially very attractive, novel tool for anticancer therapy.