XRN2 Antikörper (AA 5-748)

Produktnummer ABIN7601894

Dieses Anti-XRN2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von XRN2 in WB, ELISA und FACS. Geeignet für Human.

Kurzübersicht für XRN2 Antikörper (AA 5-748) (ABIN7601894)

Target: XRN2 (5'-3' Exoribonuclease 2 (XRN2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser XRN2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-XRN2 Antikörper

Bindungsspezifität: AA 5-748

Verwendungszweck: Anti-XRN2 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-XRN2 Antibody Picoband® (ABIN7601894). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human XRN2 recombinant protein (Position: A5-N748).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Chatterjee, S., Grosshans, H. Active turnover modulates mature microRNA activity in Caenorhabditis elegans. Nature 461: 546-549, 2009. 2. Shobuike, T., Sugano, S., Yamashita, T., Ikeda, H. Characterization of cDNA encoding mouse homolog of fission yeast dhp1+ gene: structural and functional conservation. Nucleic Acids Res. 23: 357-361, 1995. 3. West, S., Gromak, N., Proudfoot, N. J. Human 5-prime to 3-prime exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites. Nature 432: 522-525, 2004.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu XRN2

Target: XRN2 (5'-3' Exoribonuclease 2 (XRN2))

Andere Bezeichnung: XRN2

Hintergrund:

Synonyms: Proliferation-associated protein 2G4,Cell cycle protein p38-2G4 homolog,hG4-1,ErbB3-binding protein 1,PA2G4,EBP1,

Tissue Specificity: Isoform 2 is undetectable whereas isoform 1 is strongly expressed in cancer cells (at protein level). Isoform 1 and isoform 2 are widely expressed, including heart, brain, lung, pancreas, skeletal muscle, kidney, placenta and liver. .

Background: 5'-3' Exoribonuclease 2 (XRN2) also known as Dhm1-like protein is an exoribonuclease enzyme that in humans is encoded by the XRN2 gene. This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molekulargewicht: 109 kDa

Gen-ID: 22803

UniProt: Q9H0D6