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POLE2 Antikörper (AA 46-483)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch POLE2 in WB, ELISA und FACS. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.
Produktnummer ABIN7601802

Kurzübersicht für POLE2 Antikörper (AA 46-483) (ABIN7601802)

Target

Alle POLE2 Antikörper anzeigen
POLE2 (Polymerase (DNA Directed), epsilon 2 (p59 Subunit) (POLE2))

Reaktivität

Human, Maus, Ratte

Wirt

  • 9
  • 4
Kaninchen

Klonalität

  • 10
  • 3
Polyklonal

Konjugat

  • 13
Dieser POLE2 Antikörper ist unkonjugiert

Applikation

Western Blotting (WB), ELISA, Flow Cytometry (FACS)
  • Bindungsspezifität

    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 46-483

    Verwendungszweck

    Anti-POLE2 Antibody Picoband®

    Produktmerkmale

    Anti-POLE2 Antibody Picoband® (ABIN7601802). Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human POLE2 recombinant protein (Position: E46-K483). Human POLE2 shares 99.1% amino acid (aa) sequence identity with mouse POLE2.
  • Applikationshinweise

    Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Frugoni, F., Dobbs, K., Felgentreff, K., Aldhekri, H., Al Saud, B. K., Arnaout, R., Ali, A. A., Abhyankar, A., Alroqi, F., Giliani, S., Ojeda, M. M., Tsitsikov, E., Pai, S.-Y., Casanova, J. L., Notarangelo, L. D., Manis, J. P. A novel mutation in the POLE2 gene causing combined immunodeficiency. J. Allergy Clin. Immun. 137: 635-638, 2016. 2. Li, Y., Asahara, H., Patel, V. S., Zhou, S., Linn, S. Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon. J. Biol. Chem. 272: 32337-32344, 1997. 3. Stumpf, A. M. Personal Communication. Baltimore, Md. 03/26/2021.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target

    POLE2 (Polymerase (DNA Directed), epsilon 2 (p59 Subunit) (POLE2))

    Andere Bezeichnung

    POLE2

    Hintergrund

    DNA polymerase epsilon subunit 2 is an enzyme that in humans is encoded by the POLE2 gene. DNA polymerase epsilon, which is involved in DNA repair and replication, is composed of a large catalytic subunit and a small accessory subunit. The protein encoded by this gene represents the small subunit (B). Defects in this gene have been linked to colorectal cancer and to combined immunodeficiency.

    Gen-ID

    5427

    UniProt

    P56282

    Pathways

    Telomere Maintenance, DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
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