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PLCE1 Antikörper (AA 4-735)

PLCE1 Reaktivität: Human WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7601632
  • Target Alle PLCE1 Antikörper anzeigen
    PLCE1 (Phospholipase C, epsilon 1 (PLCE1))
    Bindungsspezifität
    AA 4-735
    Reaktivität
    • 2
    • 2
    • 1
    Human
    Wirt
    • 4
    Kaninchen
    Klonalität
    • 4
    Polyklonal
    Konjugat
    • 4
    Dieser PLCE1 Antikörper ist unkonjugiert
    Applikation
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA
    Verwendungszweck
    Anti-PLCE1 Antibody Picoband®
    Produktmerkmale
    Anti-PLCE1 Antibody Picoband® (ABIN7601632). Tested in WB, ELISA applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    E.coli-derived human PLCE1 recombinant protein (Position: E4-E735). Human PLCE1 shares 74.6% and 73.6% amino acid (aa) sequence identity with mouse and rat PLCE1, respectively.
    Top Product
    Discover our top product PLCE1 Primärantikörper
  • Applikationshinweise
    Western blot, 0.25-0.5 μg/mL, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Boyer, O., Benoit, G., Gribouval, O., Nevo, F., Pawtowski, A., Bilge, I., Bircan, Z., Deschenes, G., Guay-Woodford, L. M., Hall, M., Macher, M.-A., Soulami, K., Stefanidis, C. J., Weiss, R., Loirat, C., Gubler, M.-C., Antignac, C. Mutational analysis of the PLCE1 gene in steroid resistant nephrotic syndrome. J. Med. Genet. 47: 445-452, 2010. 2. Bunney, T. D., Harris, R., Lamuno Gandarillas, N., Josephs, M. B., Roe, S. M., Sorli, S. C., Paterson, H. F., Rodrigues-Lima, F., Esposito, D., Ponting, C. P., Gierschik, P., Pearl, L. H., Driscoll, P. C., Katan, M. Structural and mechanistic insights into Ras association domains of phospholipase C epsilon. Molec. Cell 21: 495-507, 2006. 3. Evellin, S., Nolte, J., Tysack, K., vom Dorp, F., Thiel, M., Oude Weernink, P. A., Jakobs, K. H., Webb, E. J., Lomasney, J. W., Schmidt, M. Stimulation of phospholipase C-epsilon by the M(3) muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B. J. Biol. Chem. 277: 16805-16813, 2002.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target
    PLCE1 (Phospholipase C, epsilon 1 (PLCE1))
    Andere Bezeichnung
    PLCE1 (PLCE1 Produkte)
    Hintergrund
    Phospholipase C epsilon 1 (PLCE1) is an enzyme that in humans is encoded by the PLCE1 gene. This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome, characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
    Molekulargewicht
    290 kDa
    Gen-ID
    51196
    UniProt
    Q9P212
    Pathways
    EGFR Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling
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