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PLCE1 Antikörper (AA 4-735)

Der Kaninchen Polyklonal Anti-PLCE1-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, PLCE1 in Proben von Human zu detektieren.
Produktnummer ABIN7601632

Kurzübersicht für PLCE1 Antikörper (AA 4-735) (ABIN7601632)

Target

Alle PLCE1 Antikörper anzeigen
PLCE1 (Phospholipase C, epsilon 1 (PLCE1))

Reaktivität

  • 3
  • 3
  • 2
Human

Wirt

  • 7
Kaninchen

Klonalität

  • 7
Polyklonal

Konjugat

  • 7
Dieser PLCE1 Antikörper ist unkonjugiert

Applikation

  • 6
  • 6
  • 5
  • 4
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA
  • Bindungsspezifität

    AA 4-735

    Verwendungszweck

    Anti-PLCE1 Antibody Picoband®

    Produktmerkmale

    Anti-PLCE1 Antibody Picoband® (ABIN7601632). Tested in WB, ELISA applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human PLCE1 recombinant protein (Position: E4-E735). Human PLCE1 shares 74.6% and 73.6% amino acid (aa) sequence identity with mouse and rat PLCE1, respectively.
  • Applikationshinweise

    Western blot, 0.25-0.5 μg/mL, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Boyer, O., Benoit, G., Gribouval, O., Nevo, F., Pawtowski, A., Bilge, I., Bircan, Z., Deschenes, G., Guay-Woodford, L. M., Hall, M., Macher, M.-A., Soulami, K., Stefanidis, C. J., Weiss, R., Loirat, C., Gubler, M.-C., Antignac, C. Mutational analysis of the PLCE1 gene in steroid resistant nephrotic syndrome. J. Med. Genet. 47: 445-452, 2010. 2. Bunney, T. D., Harris, R., Lamuno Gandarillas, N., Josephs, M. B., Roe, S. M., Sorli, S. C., Paterson, H. F., Rodrigues-Lima, F., Esposito, D., Ponting, C. P., Gierschik, P., Pearl, L. H., Driscoll, P. C., Katan, M. Structural and mechanistic insights into Ras association domains of phospholipase C epsilon. Molec. Cell 21: 495-507, 2006. 3. Evellin, S., Nolte, J., Tysack, K., vom Dorp, F., Thiel, M., Oude Weernink, P. A., Jakobs, K. H., Webb, E. J., Lomasney, J. W., Schmidt, M. Stimulation of phospholipase C-epsilon by the M(3) muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B. J. Biol. Chem. 277: 16805-16813, 2002.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target

    PLCE1 (Phospholipase C, epsilon 1 (PLCE1))

    Andere Bezeichnung

    PLCE1

    Hintergrund

    Phospholipase C epsilon 1 (PLCE1) is an enzyme that in humans is encoded by the PLCE1 gene. This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome, characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

    Molekulargewicht

    290 kDa

    Gen-ID

    51196

    UniProt

    Q9P212

    Pathways

    EGFR Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling
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