KDM4A Antikörper (AA 379-1064)

Produktnummer ABIN7601534

Dieser Anti-KDM4A Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von KDM4A in WB, IHC, ELISA und FACS. Geeignet für Human, Maus und Ratte.

Kurzübersicht für KDM4A Antikörper (AA 379-1064) (ABIN7601534)

Target: KDM4A (Lysine (K)-Specific Demethylase 4A (KDM4A))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KDM4A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Produktdetails anti-KDM4A Antikörper

Bindungsspezifität: AA 379-1064

Verwendungszweck: Anti-JHDM3A/JMJD2A/KDM4A Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-JHDM3A/JMJD2A/KDM4A Antibody Picoband® (ABIN7601534). Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human JHDM3A/JMJD2A/KDM4A recombinant protein (Position: D379-E1064).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Chen, Z., Zang, J., Whetstine, J., Hong, X., Davrazou, F., Kutateladze, T. G., Simpson, M., Mao, Q., Pan, C.-H., Dai, S., Hagman, J., Hansen, K., Shi, Y., Zhang, G. Structural insights into histone demethylation by JMJD2 family members. Cell 125: 691-702, 2006. 2. Ishikawa, K., Nagase, T., Suyama, M., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 5: 169-176, 1998. 3. Katoh, M., Katoh, M. Identification and characterization of JMJD2 family genes in silico. Int. J. Oncol. 24: 1623-1628, 2004.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu KDM4A

Target: KDM4A (Lysine (K)-Specific Demethylase 4A (KDM4A))

Andere Bezeichnung: KDM4A

Hintergrund:

Synonyms: gasdermin D, gasdermin-D

Tissue Specificity: Brain, placental, and gut tissues.

Background: Lysine-specific demethylase 4A is an enzyme that in humans is encoded by the KDM4A gene. This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.

Molekulargewicht: 150 kDa

Gen-ID: 9682

UniProt: O75164

Pathways: Warburg Effekt