STK4 Antikörper (AA 324-452)

Produktnummer ABIN7601330

Dieses Anti-STK4-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von STK4 in WB und ELISA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für STK4 Antikörper (AA 324-452) (ABIN7601330)

Target: STK4 (serine/threonine Kinase 4 (STK4))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STK4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-STK4 Antikörper

Bindungsspezifität: AA 324-452

Verwendungszweck: Anti-MST1/STK4 Antibody Picoband®

Produktmerkmale: Anti-MST1/STK4 Antibody Picoband® (ABIN7601330). Tested in WB, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human MST1/STK4 recombinant protein (Position: E324-D452). Human STK4 shares 93.8% amino acid (aa) sequence identity with mouse STK4.

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
1. Abdollahpour, H., Appaswamy, G., Kotlarz, D., Diestelhorst, J., Beier, R., Schaffer, A. A., Gertz, E. M., Schambach, A., Kreipe, H. H., Pfeifer, D., Engelhardt, K. R., Rezaei, N., Grimbacher, B., Lohrmann, S., Sherkat, R., Klein, C. The phenotype of human STK4 deficiency. Blood 119: 3450-3457, 2012. 2. Cheung, W. L., Ajiro, K., Samejima, K., Kloc, M., Cheung, P., Mizzen, C. A., Beeser, A., Etkin, L. D., Chernoff, J., Earnshaw, W. C., Allis, C. D. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell 113: 507-517, 2003. 3. Creasy, C. L., Chernoff, J. Cloning and characterization of a human protein kinase with homology to Ste20. J. Biol. Chem. 270: 21695-21700, 1995.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu STK4

Target: STK4 (serine/threonine Kinase 4 (STK4))

Andere Bezeichnung: MST1/STK4

Hintergrund: Serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the STK4 gene. The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.

Molekulargewicht: 56 kDa

Gen-ID: 6789

UniProt: Q13043

Pathways: Tube Formation