GHRH Antikörper (AA 32-75)

Produktnummer ABIN7601321

Dieses Anti-GHRH-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GHRH in WB, IHC und ELISA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für GHRH Antikörper (AA 32-75) (ABIN7601321)

Target: GHRH (Growth Hormone Releasing Hormone (GHRH))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GHRH Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-GHRH Antikörper

Bindungsspezifität: AA 32-75

Verwendungszweck: Anti-GHRH Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-GHRH Antibody Picoband® (ABIN7601321). Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human GHRH recombinant protein (Position: Y32-L75).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
1. Alba, M., Salvatori, R. A mouse with targeted ablation of the growth hormone-releasing hormone gene: a new model of isolated growth hormone deficiency. Endocrinology 145: 4134-4143, 2004. 2. Behrens, L. H., Barr, D. P. Hyperpituitarism beginning in infancy: the Alton giant. Endocrinology 16: 120-128, 1932. 3. Busto, R., Schally, A. V., Varga, J. L., Garcia-Fernandez, M. O., Groot, K., Armatis, P., Szepeshazi, K. The expression of growth hormone-releasing hormone (GHRH) and splice variants of its receptor in human gastroenteropancreatic carcinomas. Proc. Nat. Acad. Sci. 99: 11866-11871, 2002.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu GHRH

Target: GHRH (Growth Hormone Releasing Hormone (GHRH))

Andere Bezeichnung: GHRH

Hintergrund:

Synonyms: Discoidin domain-containing receptor 2, Discoidin domain receptor 2, CD167 antigen-like family member B, Discoidin domain-containing receptor tyrosine kinase 2, Neurotrophic tyrosine kinase, receptor-related 3, Receptor protein-tyrosine kinase TKT, Tyrosine-protein kinase TYRO10, CD167b, DDR2, NTRKR3, TKT, TYRO10

Tissue Specificity: Detected in osteocytes, osteoblastic cells in subchondral bone, bone lining cells, tibia and cartilage (at protein level). Detected at high levels in heart and lung, and at low levels in brain, placenta, liver, skeletal muscle, pancreas, and kidney.

Background: This gene encodes a member of the glucagon family of proteins. The encoded preproprotein is produced in the hypothalamus and cleaved to generate the mature factor, known as somatoliberin, which acts to stimulate growth hormone release from the pituitary gland. Variant receptors for somatoliberin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.

Molekulargewicht: 13-15 kDa

Gen-ID: 2691

UniProt: P01286

Pathways: Hormone Transport, Hormone Activity, cAMP Metabolic Process