CD79b Antikörper (AA 29-229)

Produktnummer ABIN7601115

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CD79b in WB und IHC. Er zeigt eine Reaktivität gegenüber Human und Ratte.

Kurzübersicht für CD79b Antikörper (AA 29-229) (ABIN7601115)

Target: CD79b (CD79B) (CD79b Molecule, Immunoglobulin-Associated beta (CD79B))

Reaktivität: Human, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD79b Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: 6H11

Produktdetails anti-CD79b Antikörper

Bindungsspezifität: AA 29-229

Verwendungszweck: Anti-CD79b Antibody Picoband®(monoclonal, 6H11)

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-CD79b Antibody Picoband® (monoclonal, 6H11) (ABIN7601115). Tested in IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human CD79b recombinant protein (Position: A29-E229). Human CD79b shares 70% amino acid (aa) sequence identity with mouse CD79b.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat
1. "Entrez Gene: CD79B CD79b molecule, immunoglobulin-associated beta" 2. Dobbs, A. K., Yang, T., Farmer, D., Kager, L., Parolini, O., Conley, M. E. Cutting edge: a hypomorphic mutation in Ig-beta (CD79b) in a patient with immunodeficiency and a leaky defect in B cell development. J. Immun. 179: 2055-2059, 2007. 3. Wood, W. J., Jr., Thompson, A. A., Korenberg, J., Chen, X., May, W., Wall, R., Denny, C. T. Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB). Genomics 16: 187-192, 1993.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu CD79b

Target: CD79b (CD79B) (CD79b Molecule, Immunoglobulin-Associated beta (CD79B))

Andere Bezeichnung: CD79B

Hintergrund:

Synonyms: B-cell antigen receptor complex-associated protein beta chain, B-cell-specific glycoprotein B29, Ig-beta, Immunoglobulin-associated B29 protein, CD79b, CD79B, B29, IGB

Tissue Specificity: Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.

Background: CD79b molecule, immunoglobulin-associated beta, also known as CD79B (Cluster of Differentiation 79B), is a human gene. By fluorescence in situ hybridization, It is mapped to 17q23.3. The CD79B protein together with the related CD79A protein, forms a dimer associated with membrane bound immunoglobulin in B-cells, thus forming the B-cell antigen receptor (BCR) which is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). CD79b also can enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.

Molekulargewicht: 35 kDa

Gen-ID: 974

UniProt: P40259

Pathways: BCR Signaling