PDGFC Antikörper (AA 288-345)

Produktnummer ABIN7601106

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PDGFC in WB, ELISA und FACS. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für PDGFC Antikörper (AA 288-345) (ABIN7601106)

Target: PDGFC (Platelet-Derived Growth Factor C (PDGFC))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDGFC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Produktdetails anti-PDGFC Antikörper

Bindungsspezifität: AA 288-345

Verwendungszweck: Anti-PDGFC Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-PDGFC Antibody Picoband® (ABIN7601106). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human PDGFC recombinant protein (Position: L288-G345).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Ding, H., Wu, X., Bostrom, H., Kim, I., Wong, N., Tsoi, B., O'Rourke, M., Koh, G. Y., Soriano, P., Betsholtz, C., Hart, T. C., Marazita, M. L., Field, L. L., Tam, P. P. L., Nagy, A. A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling. Nature Genet. 36: 1111-1116, 2004. 2. Fredriksson, L., Li, H., Fieber, C., Li, X., Eriksson, U. Tissue plasminogen activator is a potent activator of PDGF-CC. EMBO J. 23: 3793-3802, 2004. 3. Gilbertson, D. G., Duff, M. E., West, J. W., Kelly, J. D., Sheppard, P. O., Hofstrand, P. D., Gao, Z., Shoemaker, K., Bukowski, T. R., Moore, M., Feldhaus, A. L., Humes, J. M., Palmer, T. E., Hart, C. E. Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds PDGF alpha and beta receptor. J. Biol. Chem. 276: 27406-27414, 2001.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu PDGFC

Target: PDGFC (Platelet-Derived Growth Factor C (PDGFC))

Andere Bezeichnung: PDGFC

Hintergrund:

Synonyms: NADPH oxidase 5, NOX5

Tissue Specificity: Mainly expressed in pachytene spermatocytes of testis and in lymphocyte-rich areas of spleen and lymph nodes. Isoform v1 is expressed in spleen. Isoform v2 is expressed in testis. Also detected in ovary, placenta, pancreas, cardiac fibroblasts. Expressed in B-cells and prostate malignant cells. Isoform v1 and isoform v3 are expressed in epithelial colorectal adenocarcinoma cells. Isoform v2 and isoform v4 are expressed in endothelial cells. Isoform v1, isoform v2, isoform v3 and isoform v4 are expressed in pulmonary artery smooth muscle cells. Isoform v2 and isoform v5 are expressed in microvascular endothelial cells (at protein level).

Background: Platelet-derived growth factor C, also known as PDGF-C, is a 345-amino acid protein that in humans is encoded by the PDGFC gene. The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene.

Molekulargewicht: 39 kDa

Gen-ID: 56034

Pathways: RTK Signalweg, Platelet-derived growth Factor Receptor Signaling