HLA-DRA Antikörper (AA 26-254)

Produktnummer ABIN7600950

Dieser Maus Monoklonal Antikörper detektiert spezifisch HLA-DRA in WB, FACS und IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für HLA-DRA Antikörper (AA 26-254) (ABIN7600950)

Target: HLA-DRA (HLA Class II DR alpha (HLA-DRA))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HLA-DRA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC)

Klon: 8I10H1

Produktdetails anti-HLA-DRA Antikörper

Bindungsspezifität: AA 26-254

Verwendungszweck: Anti-HLA-DR/HLA-DRA Antibody (monoclonal, 8I10H1)

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-HLA-DR/HLA-DRA Antibody.(monoclonal, 8I10H1)-3. Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human HLA-DR/HLA-DRA recombinant protein (Position: I26-L254).

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu HLA-DRA

Target: HLA-DRA (HLA Class II DR alpha (HLA-DRA))

Andere Bezeichnung: HLA-DRA

Hintergrund:

Background: HLA class II histocompatibility antigen, DR alpha chainis aproteinthat in humans is encoded by the HLA-DRAgene. It is mapped to 6p21.32. HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.

Gene Full Name: major histocompatibility complex, class II, DR alpha

Molekulargewicht: 35-37 kDa

Gen-ID: 3122

UniProt: P01903

Pathways: T-Zell Rezeptor Signalweg, CXCR4-mediated Signaling Events, Human Leukocyte Antigen (HLA) in Adaptive Immune Response