Apelin Antikörper (AA 24-77)

Produktnummer ABIN7600858

Der Kaninchen Polyklonal Anti-Apelin-Antikörper wurde für IHC und ELISA validiert. Er ist geeignet, Apelin in Proben von Human zu detektieren.

Kurzübersicht für Apelin Antikörper (AA 24-77) (ABIN7600858)

Target: Apelin (APLN)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Apelin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Produktdetails anti-Apelin Antikörper

Bindungsspezifität: AA 24-77

Verwendungszweck: Anti-Apelin/APLN Antibody

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-Apelin/APLN Antibody Picoband® (ABIN7600858). Tested in ELISA, IHC applications. This antibody reacts with Human.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human Apelin/APLN recombinant protein (Position: S24-F77).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Cayabyab, M., Hinuma, S., Farzan, M., Choe, H., Fukusumi, S., Kitada, C., Nishizawa, N., Hosoya, M., Nishimura, O., Messele, T., Pollakis, G., Goudsmit, J., Fujino, M., Sodroski, J. Apelin, the natural ligand of the orphan seven-transmembrane receptor APJ, inhibits human immunodeficiency virus type 1 entry.J. Virol. 74: 11972-11976, 2000. 2. Chen, M. M., Ashley, E. A., Deng, D. X. F., Tsalenko, A., Deng, A., Tabibiazar, R., Ben-Dor, A., Fenster, B., Yang, E., King, J. Y., Fowler, M., Robbins, R., Johnson, F. L., Bruhn, L., McDonagh, T., Dargie, H., Yakhini, Z., Tsao, P. S., Quertermous, T.Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction.Circulation 108: 1432-1439, 2003. 3. De Mota, N., Reaux-Le Goazigo, A., El Messari, S., Chartrel, N., Roesch, D., Dujardin, C., Kordon, C., Vaudry, H., Moos, F., Llorens-Cortes, C. Apelin, a potent diuretic neuropeptide counteracting vasopressin actions through inhibition of vasopressin neuron activity and vasopressin release.Proc. Nat. Acad. Sci. 101: 10464-10469, 2004.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu Apelin

Target: Apelin (APLN)

Andere Bezeichnung: APLN

Hintergrund:

Synonyms: Deleted in azoospermia-like, DAZ homolog, DAZ-like autosomal, Deleted in azoospermia-like 1, SPGY-like-autosomal, DAZL, DAZH, DAZL1, DAZLA, SPGYLA

Background: Apelin is a neuropeptide expressed in the supraoptic and paraventricular nuclei that acts on specific receptors located on vasopressinergic neurons. The apelin gene to Xq25-q26.3 based on sequence similarity between the apelin sequence and a chromosome X PAC clone. This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.

Molekulargewicht: 41 kDa

Gen-ID: 8862

Pathways: Positive Regulation of Peptide Hormone Secretion, Hormone Activity, Feeding Behaviour