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SIAE Antikörper (AA 230-523)

Der Kaninchen Polyklonal Anti-SIAE-Antikörper wurde für WB, IHC und ELISA validiert. Er ist geeignet, SIAE in Proben von Human zu detektieren.
Produktnummer ABIN7600774

Kurzübersicht für SIAE Antikörper (AA 230-523) (ABIN7600774)

Target

Alle SIAE Antikörper anzeigen
SIAE (Sialic Acid Acetylesterase (SIAE))

Reaktivität

Human

Wirt

  • 14
  • 4
Kaninchen

Klonalität

  • 16
  • 2
Polyklonal

Konjugat

  • 11
  • 4
  • 3
Dieser SIAE Antikörper ist unkonjugiert

Applikation

  • 18
  • 12
  • 8
  • 5
  • 2
  • 2
  • 2
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA
  • Bindungsspezifität

    • 6
    • 2
    • 1
    • 1
    AA 230-523

    Verwendungszweck

    Anti-SIAE Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-SIAE Antibody Picoband® (ABIN7600774). Tested in ELISA, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human SIAE recombinant protein (Position: R230-K523).

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.25-0.5 μg/mL, Human
    Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Cariappa, A., Takematsu, H., Liu, H., Diaz, S., Haider, K., Boboila, C., Kalloo, G., Connole, M., Shi, H. N., Varki, N., Varki, A., Pillai, S. B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase. J. Exp. Med. 206: 125-138, 2009. 2. Surolia, I., Pirnie, S. P., Chellappa, V., Taylor, K. N., Cariappa, A., Moya, J., Liu, H., Bell, D. W., Driscoll, D. R., Diederichs, S., Haider, K., Netravali, I., and 21 others. Functionally defective germline variants of sialic acid acetylesterase in autoimmunity. Nature 466: 243-247, 2010. 3. Takematsu, H., Diaz, S., Stoddart, A., Zhang, Y., Varki, A. Lysosomal and cytosolic sialic acid 9-O-acetylesterase activities can be encoded by one gene via differential usage of a signal peptide-encoding exon at the N terminus. J. Biol. Chem. 274: 25623-25631, 1999.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • Target

    SIAE (Sialic Acid Acetylesterase (SIAE))

    Andere Bezeichnung

    SIAE

    Hintergrund

    Synonyms: BMP and activin membrane-bound inhibitor homolog, Non-metastatic gene A protein, Putative transmembrane protein, NMA, BAMBI, NMA

    Tissue Specificity: Expressed in adult liver.

    Background: This gene encodes an enzyme which removes 9-O-acetylation modifications from sialic acids. Mutations in this gene are associated with susceptibility to autoimmune disease 6. Multiple transcript variants encoding different isoforms, found either in the cytosol or in the lysosome, have been found for this gene.

    Molekulargewicht

    70 kDa

    Gen-ID

    54414
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