PRMT7 Antikörper (AA 121-526)

Produktnummer ABIN7599840

Der Kaninchen Polyklonal Anti-PRMT7-Antikörper wurde für WB, ELISA, IHC und FACS validiert. Er ist geeignet, PRMT7 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für PRMT7 Antikörper (AA 121-526) (ABIN7599840)

Target: PRMT7 (Protein Arginine Methyltransferase 7 (PRMT7))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRMT7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Produktdetails anti-PRMT7 Antikörper

Bindungsspezifität: AA 121-526

Verwendungszweck: Anti-PRMT7 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-PRMT7 Antibody Picoband® (ABIN7599840). Tested in ELISA, IHC, WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human PRMT7 recombinant protein (Position: K121-D526).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Akawi, N., McRae, J., Ansari, M., Balasubramanian, M., Blyth, M., Brady, A. F., Clayton, S., Cole, T., Deshpande, C., Fitzgerald, T. W., Foulds, N., Francis, R., and 30 others. Discovery of four recessive developmental disorders using probabilistic genotype and phenotype matching among 4,125 families. Nature Genet. 47: 1363-1369, 2015. 2. Birnbaum, R., Yosha-Orpaz, N., Yanoov-Sharav, M., Kidron, D., Gur, H., Yosovich, K., Lerman-Sagie, T., Malinger, G. Prenatal and postnatal presentation of PRMT7 related syndrome: expanding the phenotypic manifestations. Am. J. Med. Genet. 179A: 78-84, 2019. 3. Kernohan, K. D., McBride, A., Xi, Y., Martin, N., Schwartzentruber, J., Dyment, D. A., Majewski, J., Blaser, S. Care4Rare Canada Consortium, Boycott, K. M., Chitayat, D. Loss of the arginine methyltranserase (sic) PRMT7 causes syndromic intellectual disability with microcephaly and brachydactyly. Clin. Genet. 91: 708-716, 2017.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu PRMT7

Target: PRMT7 (Protein Arginine Methyltransferase 7 (PRMT7))

Andere Bezeichnung: PRMT7

Hintergrund:

Synonyms: Serine protease HTRA3,3.4.21.-,High-temperature requirement factor A3,Pregnancy-related serine protease,HTRA3,PRSP,

Tissue Specificity: Widely expressed, with highest levels in both adult and fetal heart, ovary, uterus placenta, and bladder. In the endometrium, expressed in epithelial glands and the stroma. Also present in leukocytes. Isoform 1 is predominant in heart and skeletal muscle, whereas isoform 2 is predominant in placenta and kidney. .

Background: Protein arginine methyltransferase 7 is a protein that in humans is encoded by the PRMT7 gene. This gene encodes a member of the protein arginine N-methyltransferase family of proteins. The encoded enzyme transfers single methyl groups to arginine residues to generate monomethylarginines on histone proteins as well as other protein substrates. This enzyme plays a role in a wide range of biological processes, including neuronal differentiation, male germ line imprinting, small nuclear ribonucleoprotein biogenesis, and regulation of the Wnt signaling pathway. Mutations in this gene underlie multiple related syndromes in human patients characterized by intellectual disability, short stature and other features. The encoded protein may promote breast cancer cell invasion and metastasis in human patients.

Molekulargewicht: 78 kDa

Gen-ID: 54496

Pathways: Ribonucleoprotein Complex Subunit Organization