VEGFC Antikörper (AA 108-223)

Produktnummer ABIN7599683

Der Kaninchen Polyklonal Anti-VEGFC-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, VEGFC in Proben von Maus und Ratte zu detektieren.

Kurzübersicht für VEGFC Antikörper (AA 108-223) (ABIN7599683)

Target: VEGFC (Vascular Endothelial Growth Factor C (VEGFC))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VEGFC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-VEGFC Antikörper

Bindungsspezifität: AA 108-223

Verwendungszweck: Anti-Vegfc Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-Vegfc Antibody Picoband® (ABIN7599683). Tested in ELISA, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived mouse Vegfc recombinant protein (Position: A108-R223).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
1. Balboa-Beltran, E., Fernandez-Seara, M. J., Perez-Munuzuri, A., Lago, R., Garcia-Magan, C., Couce, M. L., Sobrino, B., Amigo, J., Carracedo, A., Barros, F. A novel stop mutation in the vascular endothelial growth factor-C gene (VEGFC) results in Milroy-like disease. J. Med. Genet. 51: 475-478, 2014. Note: Erratum: J. Med. Genet. 52: 216 only, 2015. 2. Gordon, K., Schulte, D., Brice, G., Simpson, M. A., Roukens, M. G., van Impel, A., Connell, F., Kalidas, K., Jeffery, S., Mortimer, P. S., Mansour, S., Schulte-Merker, S., Ostergaard, P. Mutation in vascular endothelial growth factor-C, a ligand for vascular endothelial growth factor receptor-3, is associated with autosomal dominant Milroy-like primary lymphedema. Circ. Res. 112: 956-960, 2013. 3. Hung, C. J., Ginzinger, D. G., Zarnegar, R., Kanauchi, H., Wong, M. G., Kebebew, E., Clark, O. H., Duh, Q.-Y. Expression of vascular endothelial growth factor-C in benign and malignant thyroid tumors. J. Clin. Endocr. Metab. 88: 3694-3699, 2003.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu VEGFC

Target: VEGFC (Vascular Endothelial Growth Factor C (VEGFC))

Andere Bezeichnung: Vegfc

Hintergrund:

Synonyms: Tyrosine aminotransferase,TAT,2.6.1.5,L-tyrosine:2-oxoglutarate aminotransferase,TAT,

Background: Vascular endothelial growth factor C (VEGF-C) is a protein that is a member of the platelet-derived growth factor / vascular endothelial growth factor (PDGF/VEGF) family. It is encoded in humans by the VEGFC gene, which is located on chromosome 4q34. Enables vascular endothelial growth factor receptor 3 binding activity. Involved in several processes, including negative regulation of osteoblast differentiation, positive regulation of angiogenesis, and positive regulation of mesenchymal stem cell proliferation. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor, positive regulation of lymphangiogenesis, and positive regulation of peptidyl-tyrosine phosphorylation. Located in extracellular space. Is expressed in several structures, including alimentary system mesentery, brain, cardiovascular system, embryo mesenchyme, and genitourinary system. Used to study hereditary lymphedema. Human ortholog(s) of this gene implicated in breast carcinoma and hereditary lymphedema ID. Orthologous to human VEGFC (vascular endothelial growth factor C).

Molekulargewicht: 46 kDa

Gen-ID: 22341

UniProt: P97953

Pathways: RTK Signalweg, Signaling Events mediated by VEGFR1 and VEGFR2